Evidence map›Paper›PMID 35723777›Full record

ReviewCurrent osteoporosis reports2022

The Impacts of COVID-19 on Musculoskeletal Health.

Olatundun D Awosanya, Ushashi C Dadwal, Erik A Imel, Qigui Yu, Melissa A Kacena

Open access · bronzeAbstract readReview
In one paragraph

Review in Current osteoporosis reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
2.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 20 citations in OpenAlex.

  1. Review
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  9. Musculoskeletal and Neuropathic Pain in COVID-19.Diagnostics (Basel, Switzerland) · 2024
    Review
  10. Review
  11. Review
  12. Review
  13. Article
  14. Musculoskeletal involvement: COVID-19 and post COVID 19.Turkish journal of physical medicine and rehabilitation · 2023
    Review
  15. Article
  16. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Olatundun D AwosanyaDepartment of Orthopaedic Surgery, Indiana University School of Medicine, 635 Barnhill Drive, MS 549, Indianapolis, IN, 46202, USA.
Ushashi C DadwalDepartment of Orthopaedic Surgery, Indiana University School of Medicine, 635 Barnhill Drive, MS 549, Indianapolis, IN, 46202, USA.
Erik A ImelDepartment of Medicine, Indiana University School of Medicine, Indianapolis, IN, USA.
Qigui YuDepartment of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, IN, USA.
Melissa A KacenaDepartment of Orthopaedic Surgery, Indiana University School of Medicine, 635 Barnhill Drive, MS 549, Indianapolis, IN, 46202, USA. mkacena@iupui.edu.ORCID 0000-0001-7293-0088
Indiana University School of MedicineRichard L. Roudebush VA Medical Center · US

Funding

Quality Assurance and Quality Control Project Management: Improving Submissions and Study Conduct in the Human Subjects Research Prior Approval ProcessUL1TR002529 · NCATS · INDIANA UNIVERSITY INDIANAPOLIS · PI MOE, SHARON M, WIEHE, SARAH ELIZABETH · 2018 to 2022
$27.2M
Project-005U54DK106846 · NIDDK · INDIANA UNIVERSITY INDIANAPOLIS · PI Reuben Kapur, Karen Elizabeth Pollok · 2015 to 2026
$9.7M
Resource CoreP30AR072581 · NIAMS · INDIANA UNIVERSITY INDIANAPOLIS · PI Sharon M Moe · 2017 to 2026
$8.3M
BASIC SCIENCE STUDIES ON GENE THERAPY OF BLOOD DISEASEST32HL007910 · NHLBI · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI Roland W. Herzog, Reuben Kapur · 1999 to 2026
$7.6M
REGULATION OF HEMATOPOIETIC CELL PRODUCTIONT32DK007519 · NIDDK · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI KAPLAN, MARK H · 1986 to 2020
$7.1M
Comprehensive Training Program in Musculoskeletal ResearchT32AR065971 · NIAMS · INDIANA UNIVERSITY INDIANAPOLIS · PI ALEXANDER G ROBLING · 2015 to 2026
$4.4M
Impact of TPO Treatment on Bone Healing and Angiogenesis in Type 2 DiabetesI01BX003751 · VA · RLR VA MEDICAL CENTER · PI KACENA, MELISSA A · 2017 to 2021
–
BLRD VA I01 BX003751NCATS NIH HHS UL1 TR002529NHLBI NIH HHS T32 HL007910NIAMS NIH HHS P30 AR072581NIAMS NIH HHS T32 AR065971NIDDK NIH HHS T32 DK007519NIDDK NIH HHS U54 DK106846RRD VA IK6 RX004809
6 · The paper itself

Abstract

purpose of reviewAlthough COVID-19 was originally characterized as a respiratory disease, recent findings have shown lingering side effects in those who have recovered, and much is still unknown about the long-term consequences of the illness. Thus, the potential of unearthing multi-system dysfunction is high, with current data revealing significant impacts on musculoskeletal health. RECENT

findingsMultiple animal models of COVID-19 infection have revealed significant post-infection bone loss at several different skeletal sites. While how this loss occurred is unknown, this current review discusses the primary bone loss studies, and examines the possible mechanisms of action including: direct infection of bone marrow macrophages or hematopoietic progenitors, a proinflammatory response as a result of the COVID-19 induced cytokine storm, and/or a result of hypoxia and oxidative stress. This review will further examine how therapeutics used to treat COVID-19 affect the skeletal system. Finally, this review will examine the possible consequence that delayed care and limited healthcare accessibility has on musculoskeletal-related patient outcomes. It is important to investigate the potential impact COVID-19 infection has on musculoskeletal health.

Indexed as

COVID-19Musculoskeletal SystemHumansSARS-CoV-2BoneCOVID-19Cytokine stormMusculoskeletalOsteoclastSARS-CoV-2Skeletal systemTherapeutics

Identifiers

PMID35723777
PMCPMC9207429
OpenAlexW4283171352

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.