ArticleAngewandte Chemie (International ed. in English)2022
Probing Neuropeptide Volume Transmission In Vivo by Simultaneous Near-Infrared Light-Triggered Release and Optical Sensing.
Article in Angewandte Chemie (International ed. in English), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 29 citations in OpenAlex.
- Mapping and decoding neuropeptide signaling networks in nervous system function.Current opinion in neurobiology · 2025Review
- Lateral olivocochlear neurons modulate cochlear responses to noise exposure.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- A high-performance GRAB sensor reveals differences in the dynamics and molecular regulation between neuropeptide and neurotransmitter release.Nature communications · 2025Article
- Article
- Regulating nanoscale directional heat transfer with Janus nanoparticles.Nanoscale advances · 2024Article
- Current Status and Future Strategies for Advancing Functional Circuit MappingThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- A Biomimetic C-Terminal Extension Strategy for Photocaging Amidated Neuropeptides.Journal of the American Chemical Society · 2023Article
- Hypothermal opto-thermophoretic tweezers.Nature communications · 2023Article
- Adolescent binge drinking leads to long-lasting changes in cortical microcircuits in mice.Neuropharmacology · 2023Article
- Competition between stochastic neuropeptide signals calibrates the rate of satiation.Research square · 2023Article
- CGRP physiology, pharmacology, and therapeutic targets: migraine and beyond.Physiological reviews · 2023Review
- Understanding Neuropeptide Transmission in the Brain by Optical Uncaging and Release.ACS chemical neuroscience · 2023Review
- Hypothermal opto-thermophoretic tweezers.Research square · 2023Article
- Review of Flexible Wearable Sensor Devices for Biomedical Application.Micromachines · 2022Review
- New Technologies to Investigate Neuropeptides at Scale.ACS chemical neuroscience · 2022Article
Corrections and comments
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Authors and funding
19 authors at 5 institutions in 1 country.
Funding
Abstract
Neuropeptides are abundant signaling molecules in the central nervous system. Yet remarkably little is known about their spatiotemporal spread and biological activity. Here, we developed an integrated optical approach using Plasmonic nAnovesicles and cell-based neurotransmitter fluorescent engineered reporter (CNiFER), or PACE, to probe neuropeptide signaling in the mouse neocortex. Small volumes (fL to pL) of exogenously supplied somatostatin-14 (SST) can be rapidly released under near-infrared light stimulation from nanovesicles implanted in the brain and detected by SST2 CNiFERs with nM sensitivity. Our measurements reveal reduced but synchronized SST transmission within 130 μm, and markedly smaller and delayed transmission at longer distances. These measurements enabled a quantitative estimation of the SST loss rate due to peptide degradation and binding. PACE offers a new tool for determining the spatiotemporal scales of neuropeptide volume transmission and signaling in the brain.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.