Evidence map›Paper›PMID 35723533›Full record

ArticleThe Laryngoscope2023

Changes in Cough Airflow and Acoustics After Injection Laryngoplasty.

Anaïs Rameau, Katerina Andreadis, Alexander German, Mark S Lachs, Tony E Rosen, Michael S Pitzrick, Laurel B Symes, Holger Klinck

Open access · greenAbstract read
In one paragraph

Article in The Laryngoscope, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.8field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Early injection laryngoplasty improves swallowing outcomes in inpatients with acute vocal fold motion impairment.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2026
    Article
  3. Article
  4. Review
  5. Article
  6. Injection Laryngoplasty on Cough Strength and Swallowing Safety in Treating Glottal Insufficiency.Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Anaïs RameauDepartment of Otolaryngology-Head and Neck Surgery, Weill Cornell Medicine, Sean Parker Institute for the Voice, New York, New York, U.S.A.ORCID 0000-0003-1543-2634
Katerina AndreadisDepartment of Otolaryngology-Head and Neck Surgery, Weill Cornell Medicine, Sean Parker Institute for the Voice, New York, New York, U.S.A.ORCID 0000-0001-8586-450X
Alexander GermanDepartment of Otolaryngology-Head and Neck Surgery, Weill Cornell Medicine, Sean Parker Institute for the Voice, New York, New York, U.S.A.
Mark S LachsDivision of Geriatrics and Palliative Medicine, Department of Medicine, Weill Cornell Medicine, New York, New York, U.S.A.
Tony E RosenDepartment of Emergency Medicine, Weill Cornell Medicine, New York, New York, U.S.A.
Michael S PitzrickK. Lisa Yang Center for Conservation Bioacoustics, Cornell University, Ithaca, New York, U.S.A.
Laurel B SymesK. Lisa Yang Center for Conservation Bioacoustics, Cornell University, Ithaca, New York, U.S.A.
Holger KlinckK. Lisa Yang Center for Conservation Bioacoustics, Cornell University, Ithaca, New York, U.S.A.
Cornell University · US

Funding

Identifying Injury Patterns and Forensic Biomarkers Diagnostic of Physical Elder AbuseK76AG054866 · NIA · WEILL MEDICAL COLL OF CORNELL UNIV · PI ROSEN, ANTHONY · 2016 to 2021
$1.1M
Developing an App-Based Voice Clinical Decision Support Tool to Augment the Sensitivity of the Bedside Swallow Evaluation in Older AdultsK76AG079040 · NIA · WEILL MEDICAL COLL OF CORNELL UNIV · PI Anais Rameau · 2022 to 2026
$972k
NIA NIH HHS K76 AG054866NIA NIH HHS K76 AG079040
6 · The paper itself

Abstract

objective/hypothesisWe explored the following hypotheses in a cohort of patients undergoing injection laryngoplasty: (1) glottic insufficiency affects voluntary cough airflow dynamics and restoring glottic competence may improve parameters of cough strength, (2) cough strength can be inferred from cough acoustic signal, and (3) glottic competence changes cough sounds and correlates with spectrogram morphology. STUDY TYPE/

designProspective interventional study.

methodsSubjects with glottic insufficiency secondary to unilateral vocal fold paresis, paralysis, or atrophy, and scheduled for injection laryngoplasty completed an instrumental assessment of voluntary cough airflow using a pneumotachometer and a protocolized voluntary cough sound recording. A Wilcoxon signed-rank test was used to compare the differences between pre- and post-injection laryngoplasty in airflow and acoustic measures. A Spearman rank-order correlation was used to evaluate the association between airflow and acoustic cough measures.

resultsTwenty-five patients (13F:12M, mean age 68.8) completed voluntary cough airflow measurements and 22 completed cough sound recordings. Following injection laryngoplasty, patients had a statistically significant decreased peak expiratory flow rise time (PEFRT) (mean change: -0.03 s, SD: 0.06, p = 0.04) and increased cough volume acceleration (mean change: 13.1 L/s

conclusionsOur study thus indicates that injection laryngoplasty may help avert aspiration in patients with glottic insufficiency by improving cough effectiveness and that improved cough airflow measures may be tracked with cough sounds. LEVEL OF EVIDENCE: 3 Laryngoscope, 133:S1-S14, 2023.

Indexed as

CoughLaryngoplastyAcousticsAgedHumansProspective StudiesTreatment Outcomebioacousticscoughglottic insufficiencyinjection laryngoplasty

Identifiers

PMID35723533
PMCPMC9763552
OpenAlexW4283172239

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.