Evidence map›Paper›PMID 35723347›Full record

ArticleCurrent issues in molecular biology2022

Identification and Characterization of Polymorphisms in piRNA Regions.

José Roberto Sobrinho Lima, Jhully Azevedo-Pinheiro, Roberta Borges Andrade, André Salim Khayat, Paulo Pimentel de Assumpção, Ândrea Ribeiro-Dos-Santos, Sidney Emanuel Batista Dos Santos, Fabiano Cordeiro Moreira

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Article in Current issues in molecular biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

José Roberto Sobrinho LimaNúcleo de Pesquisas em Oncologia (NPO), Programa de Pós-Graduação em Oncologia e Ciências Médicas, Universidade Federal do Pará, Belém 66073-005, PA, Brazil.
Jhully Azevedo-PinheiroLaboratório de Genética Humana e Médica (LGHM), Programa de Pós-Graduação em Genética e Biologia Molecular, Universidade Federal do Pará, Belém 66075-110, PA, Brazil.
Roberta Borges AndradeNúcleo de Pesquisas em Oncologia (NPO), Programa de Pós-Graduação em Oncologia e Ciências Médicas, Universidade Federal do Pará, Belém 66073-005, PA, Brazil.
André Salim KhayatNúcleo de Pesquisas em Oncologia (NPO), Programa de Pós-Graduação em Oncologia e Ciências Médicas, Universidade Federal do Pará, Belém 66073-005, PA, Brazil.ORCID 0000-0002-3451-6369
Paulo Pimentel de AssumpçãoNúcleo de Pesquisas em Oncologia (NPO), Programa de Pós-Graduação em Oncologia e Ciências Médicas, Universidade Federal do Pará, Belém 66073-005, PA, Brazil.
Ândrea Ribeiro-Dos-SantosNúcleo de Pesquisas em Oncologia (NPO), Programa de Pós-Graduação em Oncologia e Ciências Médicas, Universidade Federal do Pará, Belém 66073-005, PA, Brazil.ORCID 0000-0001-7001-1483
Sidney Emanuel Batista Dos SantosNúcleo de Pesquisas em Oncologia (NPO), Programa de Pós-Graduação em Oncologia e Ciências Médicas, Universidade Federal do Pará, Belém 66073-005, PA, Brazil.ORCID 0000-0002-8622-9417
Fabiano Cordeiro MoreiraNúcleo de Pesquisas em Oncologia (NPO), Programa de Pós-Graduação em Oncologia e Ciências Médicas, Universidade Federal do Pará, Belém 66073-005, PA, Brazil.

Funding

Coordenação de Aperfeicoamento de Pessoal de Nível Superior 88887.512871/2020-00
6 · The paper itself

Abstract

piRNAs are a class of noncoding RNAs that perform functions in epigenetic regulation and silencing of transposable elements, a mechanism conserved among most mammals. At present, there are more than 30,000 known piRNAs in humans, of which more than 80% are derived from intergenic regions, and approximately 20% are derived from the introns and exons of pre-mRNAs. It was observed that the expression of the piRNA profile is specific in several organs, suggesting that they play functional roles in different tissues. In addition, some studies suggest that changes in regions that encode piRNAs may have an impact on their function. To evaluate the conservation of these regions and explore the existence of a seed region, SNP and INDEL variant rates were investigated in several genomic regions and compared to piRNA region variant rates. Thus, data analysis, data collection, cleaning, treatment, and exploration were implemented using the R programming language with the help of the RStudio platform. We found that piRNA regions are highly conserved after considering INDELs and do not seem to present an identifiable seed region after considering SNPs and INDEL variants. These findings may contribute to future studies attempting to determine how polymorphisms in piRNA regions can impact diseases.

Indexed as

conservationpiRNApolymorphisms

Identifiers

PMID35723347
PMCPMC8929088

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.