ArticleDevelopment (Cambridge, England)2022
The extra-embryonic area opaca plays a role in positioning the primitive streak of the early chick embryo.
Article in Development (Cambridge, England), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
8 citing papers in PubMed, 13 citations in OpenAlex.
- Live imaging and functional characterization of the avian hypoblast redefine the mechanisms of primitive streak induction.Nature communications · 2025Article
- Advances in mechanochemical modelling of vertebrate gastrulation.Biochemical Society transactions · 2025Article
- Control of tissue flows and embryo geometry in avian gastrulation.Nature communications · 2025Article
- Development and functions of the area opaca of the chick embryo.Developmental biology · 2025Review
- Canonical Wnt signalling from the area opaca induces and maintains the marginal zone in pre-primitive-streak stage chick embryos.Development (Cambridge, England) · 2025Article
- Downregulation of extraembryonic tension controls body axis formation in avian embryos.Nature communications · 2023Article
- Behind the developing brains and beating hearts of stem cell-derived embryo models.Open biology · 2023Article
- Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Classical studies have established that the marginal zone, a ring of extra-embryonic epiblast immediately surrounding the embryonic epiblast (area pellucida) of the chick embryo, is important in setting embryonic polarity by positioning the primitive streak, the site of gastrulation. The more external extra-embryonic region (area opaca) was thought to have only nutritive and support functions. Using experimental embryology approaches, this study reveals three separable functions for this outer region. First, juxtaposition of the area opaca directly onto the area pellucida induces a new marginal zone from the latter; this induced domain is entirely posterior in character. Second, ablation and grafting experiments using an isolated anterior half of the blastoderm and pieces of area opaca suggest that the area opaca can influence the polarity of the adjacent marginal zone. Finally, we show that the loss of the ability of such isolated anterior half-embryos to regulate (re-establish polarity spontaneously) at the early primitive streak stage can be rescued by replacing the area opaca by one from a younger stage. These results uncover new roles of chick extra-embryonic tissues in early development.
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Registered trials
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