Evidence map›Paper›PMID 35723053›Full record

ArticleExperimental biology and medicine (Maywood, N.J.)2022

TFPI and FXIII negatively and S100A8/A9 and Cystatin C positively correlate with D-dimer in COVID-19.

Anamika Gupta, Rizwan Qaisar, Rabih Halwani, Meganathan Kannan, Firdos Ahmad

Open access · greenAbstract read
In one paragraph

Article in Experimental biology and medicine (Maywood, N.J.), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.9field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 19 citations in OpenAlex.

  1. Impact of Gestational Maternal SARS-CoV-2 Infection on Neonatal Inflammatory Biomarkers.American journal of reproductive immunology (New York, N.Y. : 1989) · 2026
    Article
  2. Article
  3. Review
  4. Circulating H-FABP as a biomarker of frailty in patients with chronic heart failure.Experimental biology and medicine (Maywood, N.J.) · 2023
    Article
  5. Review
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Anamika GuptaCardiovascular Research Group, Sharjah Institute for Medical Research, University of Sharjah, Sharjah 27272, UAE.
Rizwan QaisarCardiovascular Research Group, Sharjah Institute for Medical Research, University of Sharjah, Sharjah 27272, UAE.
Rabih HalwaniDepartment of Clinical Sciences, College of Medicine, University of Sharjah, Sharjah 27272, UAE.ORCID 0000-0002-6516-7771
Meganathan KannanBlood and Vascular Biology Research Lab, Department of Life Sciences, Central University of Tamil Nadu, Thiruvarur 610005, Tamil Nadu, India.
Firdos AhmadCardiovascular Research Group, Sharjah Institute for Medical Research, University of Sharjah, Sharjah 27272, UAE.ORCID 0000-0001-6530-6068
University of Sharjah · AECentral University of Tamil Nadu · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

D-dimer is an established biomarker of thromboembolism and severity in COVID-19. We and others have recently reported the dysregulation of tissue factor pathway inhibitor (TFPI), FXIII, fibrinolytic pathway, inflammatory markers, and tissue injury markers, particularly in severe COVID-19. However, association of these markers with thromboembolism in COVID-19 remains elusive. The correlation analyses between these markers in patients with moderate (non-ICU) and severe COVID-19 (ICU) were performed to delineate the potential pathomechanisms and impact of thromboembolism. We observe a negative correlation of plasma TFPI (

Indexed as

COVID-19ThromboembolismBiomarkersCD40 LigandCystatin CEndothelial CellsFibrin Fibrinogen Degradation ProductsFibrinolysisHumansLeukocyte L1 Antigen ComplexLipoproteinsMyoglobinPlasminogenPlasminogen Activator Inhibitor 1P-SelectinTissue Plasminogen ActivatorBiomarkersCD40 LigandCystatin CFibrin Fibrinogen Degradation Productsfibrin fragment DLeukocyte L1 Antigen Complexlipoprotein-associated coagulation inhibitorLipoproteinsMyoglobinPlasminogenPlasminogen Activator Inhibitor 1P-SelectinTissue Plasminogen ActivatorcalprotectinCystatin CD-dimerFXIIITFPIthromboembolismtissue injury

Identifiers

PMID35723053
PMCPMC9554165
OpenAlexW4283160569

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.