Evidence map›Paper›PMID 35722903›Full record

ArticleJournal of neurotrauma2022

Increased Fear Generalization and Amygdala AMPA Receptor Proteins in Chronic Traumatic Brain Injury.

Ann N Hoffman, Sonya Watson, Nishtha Chavda, Jamie Lam, David A Hovda, Christopher C Giza, Michael S Fanselow

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of neurotrauma, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.9field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Ann N HoffmanDepartment of Neurosurgery, Brain Injury Research Center, University of California, Los Angeles, Los Angeles, California, USA.
Sonya WatsonDepartment of Neurosurgery, Brain Injury Research Center, University of California, Los Angeles, Los Angeles, California, USA.
Nishtha ChavdaDepartment of Psychology, University of California, Los Angeles, Los Angeles, California, USA.
Jamie LamDepartment of Psychology, University of California, Los Angeles, Los Angeles, California, USA.
David A HovdaDepartment of Neurosurgery, Brain Injury Research Center, University of California, Los Angeles, Los Angeles, California, USA.
Christopher C GizaDepartment of Neurosurgery, Brain Injury Research Center, University of California, Los Angeles, Los Angeles, California, USA.
Michael S FanselowDepartment of Psychology, University of California, Los Angeles, Los Angeles, California, USA.
University of California, Los Angeles · US

Funding

Contextual Fear Differentiation, Sex Differences and AcetylcholineR01MH062122 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI FANSELOW, MICHAEL S · 2001 to 2021
$7.3M
Using glutamatergic pharmacotherapy to optimize TBI recoveryR01NS027544 · NINDS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI HOVDA, DAVID A · 1990 to 2017
$3.8M
Contributions of auditory sensitivity to traumatic brain injusry enhanced fear learningF32NS098694 · NINDS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI HOFFMAN, ANN · 2016 to 2018
$118k
NIMH NIH HHS R01 MH062122NINDS NIH HHS F32 NS098694NINDS NIH HHS R01 NS027544
6 · The paper itself

Abstract

Cognitive impairments and emotional lability are common long-term consequences of traumatic brain injury (TBI). How TBI affects interactions between sensory, cognitive, and emotional systems may reveal mechanisms that underlie chronic mental health comorbidities. Previously, we reported changes in auditory-emotional network activity and enhanced fear learning early after TBI. In the current study, we asked whether TBI has long-term effects on fear learning and responses to novel stimuli. Four weeks following lateral fluid percussion injury (FPI) or sham surgery, adult male rats were fear conditioned to either white noise-shock or tone-shock pairing, or shock-only control and subsequently were tested for freezing to context and to the trained or novel auditory cues in a new context. FPI groups showed greater freezing to their trained auditory cue, indicating long-term TBI enhanced fear. Interestingly, FPI-Noise Shock animals displayed robust fear to the novel, untrained tone compared with Sham-Noise Shock across both experiments. Shock Only groups did not differ in freezing to either auditory stimulus. These findings suggest that TBI precipitates maladaptive associative fear generalization rather than non-associative sensitization. Basolateral amygdala (BLA) α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAr) subunits GluA1 and GluA2 levels were analyzed and the FPI-Noise Shock group had increased GluA1 (but not GluA2) levels that correlated with the level of tone fear generalization. This study illustrates a unique chronic TBI phenotype with both a cognitive impairment and increased fear and possibly altered synaptic transmission in the amygdala long after TBI, where stimulus generalization may underlie maladaptive fear and hyperarousal.

Indexed as

Brain Injuries, TraumaticBrain Injury, ChronicFearReceptors, AMPAAmygdalaAnimalsMaleRatsReceptors, AMPAAMPA receptoramygdalaassociative learningdefensive behaviorfear conditioningpost-traumatic stress

Identifiers

PMID35722903
PMCPMC9689770
OpenAlexW4283067576

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.