ArticleAlcoholism, clinical and experimental research2022
Effects of prenatal alcohol and delta-9-tetrahydrocannabinol exposure via electronic cigarettes on motor development.
Article in Alcoholism, clinical and experimental research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 24 citations in OpenAlex.
- Vaping and Smoking in Pregnancy-A Meta-Analysis of Neurobehavioural Development in Prenatally Exposed Offspring.Acta paediatrica (Oslo, Norway : 1992) · 2025Pooled it
- Persistent effects of repeated adolescent and adult heroin vapor inhalation in female Wistar rats.Psychopharmacology · 2026Article
- Innovative Methods for Prenatal Cannabis Exposure: Vapor Inhalation Chamber and Metabolite Quantification in Prairie Voles and Rats.Developmental psychobiology · 2026Article
- Anxiety, Depression, and Emotional Dysregulation Following Prenatal Substance Exposure.Advances in experimental medicine and biology · 2026Review
- Mediating the Impact of Prenatal Cannabis Exposure on Neurobehavioral Disinhibition: The Role of Delayed Developmental Milestone Attainment.Cannabis (Albuquerque, N.M.) · 2026Article
- Early life outcomes of prenatal exposure to alcohol and synthetic cannabinoids in mice.Drug and alcohol dependence reports · 2025Article
- CB1 and CB2 receptors differentially modulate the cognitive impact of maternal immune activation and perinatal cannabinoid exposure.Behavioural brain research · 2025Article
- Early Life Outcomes of Prenatal Exposure to Alcohol and Synthetic Cannabinoids in Mice.bioRxiv : the preprint server for biology · 2025Article
- The interaction of genetic sex and prenatal alcohol exposure on health across the lifespan.Frontiers in neuroendocrinology · 2023Review
- Emerging Roles of Endocannabinoids as Key Lipid Mediators for a Successful Pregnancy.International journal of molecular sciences · 2023Review
- Alcohol & cannabinoid co-use: Implications for impaired fetal brain development following gestational exposure.Experimental neurology · 2023Review
- Influence of prenatal cannabinoid exposure on early development and beyond.Advances in drug and alcohol research · 2023Review
- Prenatal alcohol and tetrahydrocannabinol exposure: Effects on spatial and working memory.Frontiers in neuroscience · 2023Article
- Prenatal ethanol exposure leads to persistent anxiety-like behavior during adulthood indicated by reduced horizontal and vertical exploratory behaviors.Frontiers in neuroscience · 2023Article
- Effects of prenatal alcohol and delta-9-tetrahydrocannabinol exposure via electronic cigarettes on motor development.Alcoholism, clinical and experimental research · 2022Article
- The impact of prenatal alcohol, synthetic cannabinoid and co-exposure on behavioral adaptations in adolescent offspring and alcohol self-administration in adulthood.Neurotoxicology and teratologyArticle
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundPrenatal alcohol exposure can lead to a wide range of neurological and behavioral deficits, including alterations in motor domains. However, much less is known about the effects of prenatal cannabis exposure on motor development, despite cannabis being the most consumed illicit drug among women. Cannabis use among pregnant women has become increasingly popular given the widespread perception that consumption is safe during pregnancy. Moreover, alcohol and cannabis are commonly used together, even among pregnant women. Yet few studies have explored the potential consequences of combined prenatal exposure on behavioral domains.
methodsUsing our previously established model, during gestational days 5 to 20, four groups of pregnant Sprague-Dawley rats were exposed to vaporized alcohol, delta-9-Tetrahydrocannabinol (THC) via electronic (e-) cigarettes, the combination of alcohol and THC, or a vehicle. Following birth, offspring were tested on early sensorimotor development, adolescent motor coordination, and adolescent activity levels.
resultsPrenatal THC e-cigarette exposure delayed sensorimotor development early in life and impaired motor coordination later in early adolescence; combined prenatal alcohol and THC exposure did not have additive effects on sensorimotor development. However, combined prenatal exposure produced hyperactivity among male offspring.
conclusionsPrenatal cannabis exposure may lead to impaired motor skills throughout early development and combined exposure with alcohol during gestation may lead to hyperactivity in early adolescence. These findings have important implications for informing pregnant women of the risks to the fetus associated with prenatal cannabis exposure, with and without alcohol, and could influence public policy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.