ArticleAnnals of geriatric medicine and research2022
Effects of Muscles on Bone Metabolism-with a Focus on Myokines.
Article in Annals of geriatric medicine and research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
15 citing papers in PubMed.
- Electrical stimulation paradigms on muscle quality and bone mineral density after spinal cord injury.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2025Trial
- Association of body composition with all-cause mortality among U.S. adults with osteoporosis or osteopenia: a population-based study.Hormones (Athens, Greece) · 2026Article
- Relationship between muscle FNDC5, FGF21 mRNA, miR-150 and bone loss after sciatic denervation.Journal of physiology and biochemistry · 2026Article
- Treadmill Exercise Enhances the Effects of Zoledronate on Bone Microarchitecture and Mechanical Strength in Ovariectomized Rat Model of Osteoporosis.Journal of functional morphology and kinesiology · 2026Article
- Effect of belt electrode-skeletal muscle electrical stimulation on fracture healing in a rat femoral fracture model.BMC musculoskeletal disorders · 2026Article
- Research progress on mitochondria in bone defect repair: mechanisms and therapeutic implications.Frontiers in bioengineering and biotechnology · 2026Review
- Circulating BMP-7 Level is Independent of Sarcopenia in Older Asian Adults.Annals of geriatric medicine and research · 2025Article
- MicroRNAs and their Modulatory Effect on the Hallmarks of Osteosarcopenia.Current osteoporosis reports · 2024Review
- Comparative Analysis of Myokines and Bone Metabolism Markers in Prepubertal Vegetarian and Omnivorous Children.Nutrients · 2024Article
- Beyond Bone: Embracing Osteosarcopenia for Comprehensive Fracture Prevention.Endocrinology and metabolism (Seoul, Korea) · 2024Article
- Physical performance and negative events in very old adults: a longitudinal study examining the ilSIRENTE cohort.Aging clinical and experimental research · 2024Article
- Sarcopenia as the Mobility Phenotype of Aging: Clinical Implications.Journal of bone metabolism · 2024Article
- Roles of Myokines and Muscle-Derived Extracellular Vesicles in Musculoskeletal Deterioration under Disuse Conditions.Metabolites · 2024Review
- Mechanisms underlying the long-term and withdrawal effects of denosumab therapy on bone.Nature reviews. Rheumatology · 2023Review
- Frailty and the Interactions between Skeletal Muscle, Bone, and Adipose Tissue-Impact on Cardiovascular Disease and Possible Therapeutic Measures.International journal of molecular sciences · 2023Review
Corrections and comments
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Authors and funding
1 author.
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Abstract
Skeletal muscles and bones, the largest tissues in the body of a non-obese person, comprise the musculoskeletal system, which allows mobility and protects internal organs. Although muscles and bones are intimately related throughout life, observations during development and aging and in human and animal disuse models have revealed the synchronization of tissue mass such that muscle phenotype changes precede alterations in bone mineral density and strength. This review discussed that mechanical forces, which have been the traditional research focus, are not the only mechanism by which muscle-derived signals may affect bone metabolism and emphasized the significance of skeletal muscles as an endocrine organ that secretes bone-regulatory factors. Consequently, both mechanical and biochemical aspects should be considered to fully understand muscle-bone crosstalk. This review also suggested that specific myokines could be ideal therapeutic targets for osteoporosis to both increase bone formation and reduce bone resorption; moreover, these myokines could also be potential circulating biomarkers to predict musculoskeletal health.
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Registered trials
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