Evidence map›Paper›PMID 35722696›Full record

ArticleCroatian medical journal2022

Croatian genetic heritage: an updated Y-chromosome story.

Dragan Primorac, Vedrana Škaro, Petar Projić, Saša Missoni, Ivana Horjan Zanki, Siniša Merkaš, Jelena Šarac, Natalija Novokmet, Andrea Ledić, Adela Makar and 13 more

Open access · diamondAbstract read
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Article in Croatian medical journal, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.9field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors at 9 institutions in 3 countries.

Dragan Primorac
Vedrana ŠkaroVedrana Škaro, Genos Ltd. DNA Laboratory, Borongajska cesta 83H, 10000 Zagreb, Croatia, vskaro@genos.hr.
Petar Projić
Saša Missoni
Ivana Horjan Zanki
Siniša Merkaš
Jelena Šarac
Natalija Novokmet
Andrea Ledić
Adela Makar
Gordan Lauc
Šimun Anđelinović
Željana Bašić
Ivana Kružić
Marijana Neuberg
Martina Smolić
Robert Smolić
Irena Hrstić
Dragan Trivanović
Rijad Konjhodžić
Lana Salihefendić
Naida Babić Jordamović
Damir Marjanović
Institute for Anthropological Research · HRUniversity of Split · HRGenos (Croatia) · HRInternational Burch University · BAPsychiatric Hospital Sveti Ivan · HRUniversity of Osijek · HRUniversity of Rijeka · HRNational Forensic Sciences University · INUniversity North · HR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimTo analyze an additional set of ˝Y-chromosome genetic markers to acquire a more detailed insight into the diversity of the Croatian population.

methodsA total of 518 Yfiler Plus profiles were genotyped. Allele frequencies, haplotype frequencies, and haplotype diversity were calculated by using the STRAF software v. 2.0.4. Genetic distances were quantified by Rst with AMOVA online tool from the YHRD. The evolutionary history was inferred with the neighbor-joining method of phylogenetic tree construction in the MEGAX software. Whit Athey's Haplogroup Predictor v. 5 was used for additional comparison with regional and other European populations.

resultsA total of 507 haplotypes were used for genetic STR analysis. An interpopulation study on 17 Y-STR markers showed the lowest genetic diversity between the Croatian and Bosnian-Herzegovinian populations and the highest between the Croatian and Irish populations. Additional interpopulation comparison with the original 27 Y-STR markers (for the population with available data) was also performed. A total of 518 haplotypes were used in the determination of haplogroup diversity. Haplogroup I with its sublineage I2a expressed the highest prevalence. The second most prevalent haplogroup was R, with its major sublineage R1a, except for the subpopulation of Hvar, where E1b1b was the second most prevalent haplogroup. Rare haplogroups also confirmed in this study were L, T, and Q. G1 was detected for the first time in the Croatian population.

conclusionWe obtained a new insight into the differences between examined subpopulations of Croatia and their possible (dis)similarities with neighboring and distant populations.

Indexed as

Chromosomes, Human, YGenetics, PopulationCroatiaGenetic VariationHaplotypesHumansMicrosatellite RepeatsPhylogeny

Identifiers

PMID35722696
PMCPMC9284021
OpenAlexW4283208653

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.