ArticleFrontiers in psychiatry2022
Abnormal Reginal Homogeneity in Left Anterior Cingulum Cortex and Precentral Gyrus as a Potential Neuroimaging Biomarker for First-Episode Major Depressive Disorder.
Article in Frontiers in psychiatry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Decomposing neuroanatomical heterogeneity in depression: insights from an ENIGMA major depressive disorder working group study in 5146 individuals.Translational psychiatry · 2026Article
- [Longitudinal moderating effect of depressive symptoms on the predictive relationship between self-concept clarity and meaning in life].Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2026Article
- Resting-state brain activity as a biomarker of chronic pain impairment and a mediator of its association with pain resilience.Human brain mapping · 2024Article
- Neural Functioning in Late-Life Depression: An Activation Likelihood Estimation Meta-Analysis.Geriatrics (Basel, Switzerland) · 2024Review
- Functional and structural alterations in different durations of untreated illness in the frontal and parietal lobe in major depressive disorder.European archives of psychiatry and clinical neuroscience · 2024Article
- Brain function abnormalities and inflammation in HIV-positive men who have sex with men with depressive disorders.Frontiers in psychiatry · 2024Article
- Regions with Altered Degree Centrality and Their Functional Connectivity in First-Episode Drug-Naïve Major Depressive Disorder: A Resting-State Functional Magnetic Resonance Imaging Study.Alpha psychiatry · 2023Article
- Disrupted interhemispheric coordination of sensory-motor networks and insula in major depressive disorder.Frontiers in neuroscience · 2023Article
- Resting state functional connectivity as a marker of internalizing disorder onset in high-risk youth.Scientific reports · 2022Article
- Cerebral blood flow and cardiovascular risk effects on resting brain regional homogeneity.NeuroImage · 2022Article
- Abnormal degree centrality values as a potential imaging biomarker for major depressive disorder: A resting-state functional magnetic resonance imaging study and support vector machine analysis.Frontiers in psychiatry · 2022Article
- Multiple examinations indicated associations between abnormal regional homogeneity and cognitive dysfunction in major depressive disorder.Frontiers in psychology · 2022Article
- Gender differences in major depressive disorders: A resting state fMRI study.Frontiers in psychiatry · 2022Article
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5 authors.
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Abstract
Objective: There is no objective method to diagnose major depressive disorder (MDD). This study explored the neuroimaging biomarkers using the support vector machine (SVM) method for the diagnosis of MDD. Methods: 52 MDD patients and 45 healthy controls (HCs) were involved in resting-state functional magnetic resonance imaging (rs-fMRI) scanning. Imaging data were analyzed with the regional homogeneity (ReHo) and SVM methods. Results: Compared with HCs, MDD patients showed increased ReHo in the left anterior cingulum cortex (ACC) and decreased ReHo in the left precentral gyrus (PG). No correlations were detected between the ReHo values and the Hamilton Rating Scale for Depression (HRSD) scores. The SVM results showed a diagnostic accuracy of 98.96% (96/97). Increased ReHo in the left ACC, and decreased ReHo in the left PG were illustrated, along with a sensitivity of 98.07%(51/52) and a specificity of100% (45/45). Conclusion: Our results suggest that abnormal regional neural activity in the left ACC and PG may play a key role in the pathophysiological process of first-episode MDD. Moreover, the combination of ReHo values in the left ACC and precentral gyrusmay serve as a neuroimaging biomarker for first-episode MDD.
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