ArticleFrontiers in psychiatry2022
Rethinking Our Concepts and Assumptions About Autism.
Article in Frontiers in psychiatry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
9 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Predicting early intervention outcomes in autism via individual participant data mega-analysis.Molecular autism · 2026Pooled it
- Ableism in Applied Behavior Analysis: Historical Context of Services for Autistic People.Behavior analysis in practice · 2026Review
- On Terms: Is There a Problem With "Problem Behavior"? A Bibliometric Prevalence Analysis.Journal of autism and developmental disorders · 2026Article
- A 3D approach to understanding heterogeneity in early developing autisms.Molecular autism · 2024Article
- Enhanced motor noise in an autism subtype with poor motor skills.Molecular autism · 2024Article
- Effects of Physical Exercise on Gross Motor Skills in Children with Autism Spectrum Disorder.Journal of autism and developmental disorders · 2024Article
- Moving from Disorder to Difference: A Systematic Review of Recent Language Use in Autism Research.Autism in adulthood · 2024Article
- Clinical correlates of diagnostic certainty in children and youths with Autistic Disorder.Molecular autism · 2024Article
- A molecular framework for autistic experiences: Mitochondrial allostatic load as a mediator between autism and psychopathology.Frontiers in psychiatry · 2022Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Autism is a clinical consensus diagnosis made based on behavioral symptoms of early developmental difficulties in domains of social-communication (SC) and restricted repetitive behaviors (RRB). Many readily assume that alongside being optimal for separating individuals based on SC and RRB behavioral domains, that the label should also be highly useful for explaining differential biology, outcomes, and treatment (BOT) responses. However, we also now take for granted the fact that the autism population is vastly heterogeneous at multiple scales, from genome to phenome. In the face of such multi-scale heterogeneity, here we argue that the concept of autism along with the assumptions that surround it require some rethinking. While we should retain the diagnosis for all the good it can do in real-world circumstances, we also call for the allowance of multiple other possible definitions that are better tailored to be highly useful for other translational end goals, such as explaining differential BOT responses.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.