Evidence map›Paper›PMID 35722397›Full record

ArticleAnnals of translational medicine2022

Potential prognostic value of the lymph node ratio and its correlation with circulating sex hormone concentration in pathological T1/2 breast cancer patients: a retrospective study.

Wangyu Zhu, Xia Qiu, Nawa Lin, Kexin Fang, Tinglei Zhang, Naohiro Ishii, Warren Matthew Rozen, Alireza Hamidian Jahromi, Jian Huang

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
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Article in Annals of translational medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
0.1field-weighted citation impact, top 62% of its field
1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

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0 citing papers in PubMed, 1 citations in OpenAlex.

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4 · The record

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5 · Who and what money

Authors and funding

9 authors at 5 institutions in 4 countries.

Wangyu ZhuKey Laboratory of Tumor Microenvironment and Immune Therapy of Zhejiang Province, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
Xia QiuDepartment of Breast Surgery, Zhoushan Hospital, Zhoushan, China.
Nawa LinCell and Molecular Biology Laboratory, Zhoushan Hospital, Zhoushan, China.
Kexin FangCell and Molecular Biology Laboratory, Zhoushan Hospital, Zhoushan, China.
Tinglei ZhangCell and Molecular Biology Laboratory, Zhoushan Hospital, Zhoushan, China.
Naohiro IshiiDepartment of Plastic and Reconstructive Surgery, International University of Health and Welfare Hospital, Tochigi, Japan.
Warren Matthew RozenDepartment of Surgery, Peninsula Campus, Central Clinical School, Monash University, Frankston Victoria, Australia.
Alireza Hamidian JahromiDivision of Plastic and Reconstructive Surgery, Temple University Hospitals, Philadelphia, PA, USA.
Jian HuangKey Laboratory of Tumor Microenvironment and Immune Therapy of Zhejiang Province, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
Zhoushan Hospital · CNInternational University of Health and Welfare · JPMonash University · AUSecond Affiliated Hospital of Zhejiang University · CNTemple University Hospital · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: The lymph node ratio (LNR) is an additional informative factor complementing anatomic TNM staging in breast cancer patients. The aim of this study was to evaluate the role of LNR in the cancer-specific and overall survival (OS) in a cohort of pT1/2 breast cancer patients and examine its correlation with circulating sex hormone concentrations in postmenopausal cases of the cohort from eastern China islands. Methods: Clinical and pathological characteristics, preoperational sex hormone and tumor markers concentrations, and breast cancer-specific survival (BCSS) and OS were analyzed retrospectively in 732 pathological T1/2 breast cancer patients. Results: The LNR was calculated, and the cut-off value was defined as 0.042 by receiver operative characteristic (ROC) curve according to the patient's mortalities. Patients with LNR ≥0.042 exhibited worse BCSS and OS than others (P<0.001) in pT1/2 breast cancer. Among patients with non-triple negative breast cancer (TNBC) and TNBC subtypes, the LNR ≥0.042 group also exhibited worse BCSS and OS than the LNR <0.042 group (P=0.003, 0.001, and P=0.032, 0.001, respectively). In univariate analysis, unfavorable BCSS and OS were both related with LNR ≥0.042 (P=0.001, <0.001). However multivariate analysis demonstrated TNBC subtypes were independent predictor for BCSS and OS [hazard ratio (HR) =1.449, 95% CI: 1.097-1.914, P=0.009; HR =1.365, 95% CI: 1.093-1.705, P=0.006, respectively]. Notably, Pearson or spearman correlation analysis revealed follicle-stimulating hormone (FSH) and, luteinizing hormone (LH) levels were significantly negatively associated with the LNR (P=0.007, 0.011, respectively) in postmenopausal cases, whereas CA153, CA125 and CEA were positively correlated with it (P<0.001, <0.001, 0.001, respectively) in all cases. Conclusions: Among pT1/2 breast cancer patients from eastern China islands, the LNR is a predictive prognosis factor; a higher LNR seems to correlate with a worse survival outcome both overall and in the subgroups. Strikingly, the current results reveal that serum FSH and LH level inversely associated with axillary node invasion in postmenopausal cases, whereas tumor markers directly related with it. The LNR is an informative factor complementing TNM staging.

Indexed as

lymph node ratioPathological T1/2 breast cancerprognosissex hormone concentrationsurvival

Identifiers

PMID35722397
PMCPMC9201154
OpenAlexW4281694884

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.