ArticlePhotoacoustics2022
Two-step proximal gradient descent algorithm for photoacoustic signal unmixing.
Article in Photoacoustics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Maximum fluence for accurate functional photoacoustic microscopy.Photoacoustics · 2026Article
- Multifocal Optical-Resolution Photoacoustic Microscopy With a Masked Single-Element Transducer.IEEE transactions on medical imaging · 2026Article
- All-fiber three-wavelength laser for functional photoacoustic microscopy.Photoacoustics · 2025Article
- Light on Alzheimer's disease: from basic insights to preclinical studies.Frontiers in aging neuroscience · 2024Review
- Super-Low-Dose Functional and Molecular Photoacoustic Microscopy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023Article
- Simultaneous dual-modal photoacoustic and harmonic ultrasound microscopy with an optimized acoustic combiner.Biomedical optics express · 2023Article
- Article
- Array-based high-intensity focused ultrasound therapy system integrated with real-time ultrasound and photoacoustic imaging.Biomedical optics express · 2023Article
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Authors and funding
6 authors.
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Abstract
Photoacoustic microscopy uses multiple wavelengths to measure concentrations of different absorbers. The speed of sound limits the shortest wavelength switching time to sub-microseconds, which is a bottleneck for high-speed broad-spectrum imaging. Via computational separation of overlapped signals, we can break the sound-speed limit on the wavelength switching time. This paper presents a new signal unmixing algorithm named two-step proximal gradient descent. It is advantageous in separating multiple wavelengths with long overlapping and high noise. In the simulation, we can unmix up to nine overlapped signals and successfully separate three overlapped signals with 12-ns delay and 15.9-dB signal-to-noise ratio. We apply this technique to separate three-wavelength photoacoustic images in microvessels. In vivo results show that the algorithm can successfully unmix overlapped multi-wavelength photoacoustic signals, and the unmixed data can improve accuracy in oxygen saturation imaging.
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