Evidence map›Paper›PMID 35722109›Full record

ArticleFrontiers in cardiovascular medicine2022

Single Cell Transcriptomic Analysis Reveals Organ Specific Pericyte Markers and Identities.

Seung-Han Baek, Enrico Maiorino, Hyunbum Kim, Kimberly Glass, Benjamin A Raby, Ke Yuan

Open access · goldAbstract read
In one paragraph

Article in Frontiers in cardiovascular medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 61 papers.

0numbers the graph read from it
0cells of the map it votes in
61citing papers in PubMed
7.5field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

61 citing papers in PubMed, 87 citations in OpenAlex.

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  15. Pericytes and Lung Vascular Remodeling.Arteriosclerosis, thrombosis, and vascular biology · 2026
    Review
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1 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Seung-Han BaekDivision of Pulmonary Medicine, Department of Pediatrics, Boston Children's Hospital and Harvard Medical School, Boston, MA, United States.
Enrico MaiorinoChanning Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, United States.
Hyunbum KimDivision of Pulmonary Medicine, Department of Pediatrics, Boston Children's Hospital and Harvard Medical School, Boston, MA, United States.
Kimberly GlassChanning Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, United States.
Benjamin A RabyDivision of Pulmonary Medicine, Department of Pediatrics, Boston Children's Hospital and Harvard Medical School, Boston, MA, United States.
Ke YuanDivision of Pulmonary Medicine, Department of Pediatrics, Boston Children's Hospital and Harvard Medical School, Boston, MA, United States.
Boston Children's Hospital · USBrigham and Women's Hospital · US

Funding

The Integrative Genomics of Acute Asthma ControlR01HL118455 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI MILLSTEIN, JOSHUA, RABY, BENJAMIN ALEXANDER · 2014 to 2024
$6.5M
Leveraging Variant-perturbed Gene Regulation to Support Precision Medicine in COPDR01HL155749 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI Kimberly Renee Glass · 2022 to 2026
$4.2M
Pericytes differentiate into smooth muscle cells through HIF2a/SDF1 activationR01HL150106 · NHLBI · BOSTON CHILDREN'S HOSPITAL · PI YUAN, KE · 2021 to 2025
$2.2M
NHLBI NIH HHS R01 HL118455NHLBI NIH HHS R01 HL150106NHLBI NIH HHS R01 HL155749
6 · The paper itself

Abstract

Pericytes are mesenchymal-derived mural cells that wrap around capillaries and directly contact endothelial cells. Present throughout the body, including the cardiovascular system, pericytes are proposed to have multipotent cell-like properties and are involved in numerous biological processes, including regulation of vascular development, maturation, permeability, and homeostasis. Despite their physiological importance, the functional heterogeneity, differentiation process, and pathological roles of pericytes are not yet clearly understood, in part due to the inability to reliably distinguish them from other mural cell populations. Our study focused on identifying pericyte-specific markers by analyzing single-cell RNA sequencing data from tissue-specific mouse pericyte populations generated by the Tabula Muris Senis. We identified the mural cell cluster in murine lung, heart, kidney, and bladder that expressed either of two known pericyte markers,

Indexed as

heartlungpericytessingle cell RNA sequencingtissue-specific

Identifiers

PMID35722109
PMCPMC9199463
OpenAlexW4281764220

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.