Evidence map›Paper›PMID 35722017›Full record

ArticleACS omega2022

Toward the Total Synthesis of Alpkinidine: Michael Addition to Isoquinolinetrione CE Ring-System Synthons.

Marco Buccini, Francis Dhoro, Louisa Tham, Brian W Skelton, Craig M Williams, Matthew J Piggott

Abstract read
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In one paragraph

Article in ACS omega, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Marco BucciniChemistry, School of Molecular Sciences, University of Western Australia, Perth 6009, Australia.
Francis DhoroChemistry, School of Molecular Sciences, University of Western Australia, Perth 6009, Australia.
Louisa ThamChemistry, School of Molecular Sciences, University of Western Australia, Perth 6009, Australia.
Brian W SkeltonChemistry, School of Molecular Sciences, University of Western Australia, Perth 6009, Australia.
Craig M WilliamsSchool of Chemistry and Molecular Biosciences, University of Queensland, Brisbane, Queensland 4072, Australia.ORCID https://orcid.org/0000-0002-3834-7398
Matthew J PiggottChemistry, School of Molecular Sciences, University of Western Australia, Perth 6009, Australia.ORCID https://orcid.org/0000-0002-5857-7051

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Strategies toward the total synthesis of the marine pyrroloacridine alkaloid alpkinidine have been explored, focusing on linking quinonoid CE ring-system synthons with the A ring, followed by condensation to form the B and D rings. The key Michael addition of the ester enolate derived from ethyl

Identifiers

PMID35722017
PMCPMC9202020

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.