Evidence map›Paper›PMID 35721835›Full record

ArticleBrain and neuroscience advances

Dissociating reward sensitivity and negative urgency effects on impulsivity in the five-choice serial reaction time task.

Chiara Toschi, Mona El-Sayed Hervig, Thiago Burghi, Torben Sell, Matthew Dominic Lycas, Parisa Moazen, Li Huang, Ulrik Gether, Trevor W Robbins, Jeffrey W Dalley

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain and neuroscience advances. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.6field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 6 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 3 countries.

Chiara ToschiDepartment of Psychology, Behavioural and Clinical Neuroscience Institute, University of Cambridge, Cambridge, UK.ORCID https://orcid.org/0000-0003-4243-2701
Mona El-Sayed HervigDepartment of Psychology, Behavioural and Clinical Neuroscience Institute, University of Cambridge, Cambridge, UK.
Thiago BurghiDepartment of Engineering, University of Cambridge, Cambridge, UK.
Torben SellSchool of Mathematics, University of Edinburgh, Edinburgh, UK.ORCID https://orcid.org/0000-0002-2288-3428
Matthew Dominic LycasDepartment of Neuroscience, University of Copenhagen, Copenhagen, Denmark.
Parisa MoazenDepartment of Physiology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran.ORCID https://orcid.org/0000-0002-2030-5026
Li HuangDepartment of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK.
Ulrik GetherDepartment of Neuroscience, University of Copenhagen, Copenhagen, Denmark.
Trevor W RobbinsDepartment of Psychology, Behavioural and Clinical Neuroscience Institute, University of Cambridge, Cambridge, UK.
Jeffrey W DalleyDepartment of Psychology, Behavioural and Clinical Neuroscience Institute, University of Cambridge, Cambridge, UK.ORCID https://orcid.org/0000-0002-2282-3660
University of Cambridge · GBUniversity of Copenhagen · DKTarbiat Modares University · IRUniversity of Edinburgh · GB

Funding

Medical Research Council G1000183
6 · The paper itself

Abstract

Negative urgency describes the tendency for rash and impulsive behaviour during negative emotional states and has been linked to a number of psychiatric disorders. However, there has been limited research on negative urgency as an explanatory mechanism for impulsivity in experimental animals. Such research has important implications for elucidating the neurobiology of negative urgency and thereby the development of future therapeutic interventions. In this study, we investigated the effects of negative urgency using a partial reinforcement schedule to increase the frequency of non-rewarded (i.e. frustrative) trials in the five-choice serial reaction time task, a widely used task to assess visual attention and impulsivity. Using a Markov chain model to analyse trial-by-trial outcomes we found that premature (i.e. impulsive) responses in the five-choice serial reaction time task were more likely to occur after a non-rewarded trial, and mostly after a previous premature trial. However, contrary to the frustration hypothesis of negative urgency, increasing the probability of reinforcement (

Indexed as

behavioural activationdopaminefrustrative non-rewardMarkov chainpartial reinforcementPremature responding

Identifiers

PMID35721835
PMCPMC9201310
OpenAlexW4283216350

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.