SynthesisFrontiers in endocrinology2022
The Influence of Triclosan on the Thyroid Hormone System in Humans - A Systematic Review.
Synthesis in Frontiers in endocrinology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed, 16 citations in OpenAlex.
- Antiseptics Prescription for the Prevention and Treatment of Periodontal Diseases: A Comprehensive Review.Health science reports · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objectives: Triclosan is an antibacterial agent suspected to disrupt the endocrine system. The aim of this study was to investigate the influence of triclosan on the human thyroid system through a systematic literature review of human studies. Methods: Eligibility criteria and method of analysis were registered at Prospero (registration number: CRD42019120984) before a systematic search was conducted in Pubmed and Embase in October 2020. Seventeen articles were found eligible for inclusion. Thirteen studies were observational, while four had a triclosan intervention. Participants consisted of pregnant women in eight studies, of men and non-pregnant women in seven studies and of chord samples/newborns/children/adolescents in six studies. The outcomes were peripheral thyroid hormones and thyroid-stimulating hormone (TSH) in blood samples. Results: Several studies found a negative association between triclosan and triiodothyronine and thyroxine, and a positive association with TSH; however, the opposite associations or no associations were also found. In general, the studies had limited measurement timepoints of thyroid outcomes, and the interventional studies used low concentrations of triclosan. Thus, study design limitations influence the quality of the dataset and it is not yet possible to conclude whether triclosan at current human exposure levels adversely affects the thyroid hormone system. Conclusions: Further larger studies with more continuity and more elaborate outcome measurements of thyroid function are needed to clarify whether triclosan, at current exposure levels, affects the human thyroid hormone system. Systematic Review Registration: http://www.crd.york.ac.uk/PROSPERO/display_record.asp?ID=CRD42019120984, identifier PROSPERO (CRD42019120984).
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.