Evidence map›Paper›PMID 35721746›Full record

ReviewFrontiers in endocrinology2022

The Role of Thyroglobulin in Preoperative and Postoperative Evaluation of Patients With Differentiated Thyroid Cancer.

Sha Li, Chutong Ren, Yi Gong, Fei Ye, Yulong Tang, Jiangyue Xu, Can Guo, Jiangsheng Huang

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Frontiers in endocrinology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 1 pooled it
4.9field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 1 synthesis or guideline pooled it, 38 citations in OpenAlex.

  1. The Role of Thyroidectomy in the Management of Thyroglossal Duct Carcinoma: A Systematic Review.Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Sha LiDepartment of Thyroid Surgery, The Second Xiangya Hospital of Central South University, Changsha, China.
Chutong RenDepartment of Thyroid Surgery, The Second Xiangya Hospital of Central South University, Changsha, China.
Yi GongDepartment of Thyroid Surgery, The Second Xiangya Hospital of Central South University, Changsha, China.
Fei YeDepartment of Thyroid Surgery, The Second Xiangya Hospital of Central South University, Changsha, China.
Yulong TangDepartment of Thyroid Surgery, The Second Xiangya Hospital of Central South University, Changsha, China.
Jiangyue XuDepartment of Thyroid Surgery, The Second Xiangya Hospital of Central South University, Changsha, China.
Can GuoDepartment of Thyroid Surgery, The Second Xiangya Hospital of Central South University, Changsha, China.
Jiangsheng HuangDepartment of Thyroid Surgery, The Second Xiangya Hospital of Central South University, Changsha, China.
Central South University · CNSecond Xiangya Hospital of Central South University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Thyroglobulin (Tg) is secreted by thyroid follicular cells and stored in the thyroid follicular lumen as a component of thyroid hormone. It is known that both benign and well-differentiated malignant thyroid tissue can secrete Tg. In recent years, growing lines of evidence have shown that Tg plays an important role in the diagnosis and metastasis of preoperative differentiated thyroid carcinoma (DTC). The levels of Tg, whether in the serum or in a fine-needle aspiration washout fluid, are usually viewed as an excellent indicator in the monitoring of postoperative DTC, including the guidance and evaluation of radioactive iodine ablation. Nevertheless, some factors limit the application of Tg, such as the method used to measure Tg and the presence of Tg antibodies. This review aimed to summarize the role of Tg in the preoperative and postoperative evaluation of patients with DTC, and the factors influencing Tg. This review could provide a reference for a more accurate application of Tg in patients with DTC.

Indexed as

Adenocarcinoma, FollicularThyroid NeoplasmsBiopsy, Fine-NeedleHumansIodine RadioisotopesThyroglobulinIodine RadioisotopesThyroglobulindifferentiated thyroid carcinomapostoperative evaluationpreoperative evaluationrolethyroglobulin

Identifiers

PMID35721746
PMCPMC9200986
OpenAlexW4281651778

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.