Evidence map›Paper›PMID 35721730›Full record

ArticleFrontiers in endocrinology2022

Epstein-Barr Virus-Encoded BILF1 Orthologues From Porcine Lymphotropic Herpesviruses Display Common Molecular Functionality.

Maša Mavri, Valentina Kubale, Daniel P Depledge, Jianmin Zuo, Christene A Huang, Judith Breuer, Milka Vrecl, Michael A Jarvis, Eva Jarc Jovičić, Toni Petan and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in endocrinology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.7field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
  2. Complex G-protein signaling of the adhesion GPCR, ADGRA3.The Journal of biological chemistry · 2025
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 9 institutions in 5 countries.

Maša MavriInstitute of Preclinical Sciences, Veterinary Faculty, University of Ljubljana, Ljubljana, Slovenia.
Valentina KubaleInstitute of Preclinical Sciences, Veterinary Faculty, University of Ljubljana, Ljubljana, Slovenia.
Daniel P DepledgeDepartment of Medicine, New York University School of Medicine, New York, NY, United States.
Jianmin ZuoInstitute of Immunology and Immunotherapy, College of Medical and Dental Sciences, University of Birmingham, Birmingham, United Kingdom.
Christene A HuangDepartment of Surgery, Division of Plastic & Reconstructive Surgery, Division of Transplant Surgery, Anschutz Medical Campus, University of Colorado, Denver, CO, United States.
Judith BreuerDivision of Infection and Immunity, University College London, London, United Kingdom.
Milka VreclInstitute of Preclinical Sciences, Veterinary Faculty, University of Ljubljana, Ljubljana, Slovenia.
Michael A JarvisThe Vaccine Group Ltd, Plymouth; and the University of Plymouth, Plymouth, United Kingdom.
Eva Jarc JovičićDepartment of Molecular and Biomedical Sciences, Jožef Stefan Institute, Ljubljana, Slovenia.
Toni PetanDepartment of Molecular and Biomedical Sciences, Jožef Stefan Institute, Ljubljana, Slovenia.
Bernhard EhlersDivision 12, Measles, Mumps, Rubella, and Viruses Affecting Immunocompromised Patients, Robert Koch Institute, Berlin, Germany.
Mette M RosenkildeDepartment of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Katja SpiessDepartment of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
University of Ljubljana · SIJožef Stefan Institute · SIUniversity of Copenhagen · DKNew York University · USRobert Koch Institute · DEUniversity College London · GBUniversity of Birmingham · GBUniversity of Colorado Anschutz Medical Campus · USUniversity of Plymouth · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Infection of immunosuppressed transplant patients with the human γ-herpesvirus Epstein-Barr virus (EBV) is associated with post-transplant lymphoproliferative disease (PTLD), an often fatal complication. Immunosuppressed miniature pigs infected with γ-herpesvirus porcine lymphotropic herpesvirus 1 (PLHV1) develop a similar disease, identifying pigs as a potential preclinical model for PTLD in humans. BILF1 is a G protein-coupled receptor (GPCR) encoded by EBV with constitutive activity linked to tumorigenesis and immunoevasive function downregulating MHC-I. In the present study, we compared BILF1-orthologues encoded by the three known PLHVs (PLHV1-3) with EBV-BILF1 to determine pharmacological suitability of BILF1 orthologues as model system to study EBV-BILF1 druggability. Cell surface localization, constitutive internalization, and MHC-I downregulation as well as membrane proximal constitutive Gα

Indexed as

Epstein-Barr Virus InfectionsHerpesviridaeAnimalsHerpesvirus 4, HumanHumansReceptors, G-Protein-CoupledSwineViral ProteinsReceptors, G-Protein-CoupledViral ProteinsBILF1drug targetEpstein-Barr virusG protein signalingin-vivo modelMHC class Iporcine lymphotropic herpesviruses (PLHV)post-transplant lymphoproliferative disease

Identifiers

PMID35721730
PMCPMC9204316
OpenAlexW4282053035

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.