Evidence map›Paper›PMID 35721701›Full record

ArticleFrontiers in endocrinology2022

DRD2 Agonist Cabergoline Abolished the Escape Mechanism Induced by mTOR Inhibitor Everolimus in Tumoral Pituitary Cells.

Federica Mangili, Emanuela Esposito, Donatella Treppiedi, Rosa Catalano, Giusy Marra, Genesio Di Muro, Anna Maria Barbieri, Marco Locatelli, Andrea G Lania, Alessandra Mangone and 4 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in endocrinology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
0.9field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 11 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Review
  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 4 institutions in 1 country.

Federica MangiliDepartment of Clinical Sciences and Community Health, University of Milan, Milan, Italy.
Emanuela EspositoDepartment of Clinical Sciences and Community Health, University of Milan, Milan, Italy.
Donatella TreppiediDepartment of Clinical Sciences and Community Health, University of Milan, Milan, Italy.
Rosa CatalanoDepartment of Clinical Sciences and Community Health, University of Milan, Milan, Italy.
Giusy MarraDepartment of Clinical Sciences and Community Health, University of Milan, Milan, Italy.
Genesio Di MuroDepartment of Clinical Sciences and Community Health, University of Milan, Milan, Italy.
Anna Maria BarbieriDepartment of Clinical Sciences and Community Health, University of Milan, Milan, Italy.
Marco LocatelliNeurosurgery Unit, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.
Andrea G LaniaDepartment of Biomedical Sciences, Humanitas University, Pieve Emanuele, Italy.
Alessandra MangoneDepartment of Clinical Sciences and Community Health, University of Milan, Milan, Italy.
Anna SpadaDepartment of Clinical Sciences and Community Health, University of Milan, Milan, Italy.
Maura ArosioDepartment of Clinical Sciences and Community Health, University of Milan, Milan, Italy.
Erika PeverelliDepartment of Clinical Sciences and Community Health, University of Milan, Milan, Italy.
Giovanna MantovaniDepartment of Clinical Sciences and Community Health, University of Milan, Milan, Italy.
University of Milan · ITIRCCS Humanitas Research Hospital · ITIstituti di Ricovero e Cura a Carattere Scientifico · ITOspedale Maggiore · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The mammalian target of rapamycin (mTOR) inhibitor everolimus has been shown to display antiproliferative effects on a wide spectrum of tumors.

Indexed as

CabergolineEverolimusNeuroendocrine TumorsPituitary NeoplasmsReceptors, Dopamine D2TOR Serine-Threonine Kinasesbeta-Arrestin 2Drug InteractionsHumansProto-Oncogene Proteins c-aktbeta-Arrestin 2CabergolineDRD2 protein, humanEverolimusMTOR protein, humanProto-Oncogene Proteins c-aktReceptors, Dopamine D2TOR Serine-Threonine KinasesAKT phosphorylationcabergolinedopamine receptor type 2everolimusmTOR inhibitorspituitary neuroendocrine tumors

Identifiers

PMID35721701
PMCPMC9204243
OpenAlexW4281644793

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.