Evidence map›Paper›PMID 35721569›Full record

ArticleFrontiers in physiology2022

PERIOD Phosphoclusters Control Temperature Compensation of the

Radhika Joshi, Yao D Cai, Yongliang Xia, Joanna C Chiu, Patrick Emery

Open access · goldAbstract read
In one paragraph

Article in Frontiers in physiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.1field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 12 citations in OpenAlex.

  1. Oligomerization of PER2 as a dynamic mode of regulation of the mammalian circadian clock.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  2. Review
  3. Post-Translational Modifications in Animal Circadian Clocks.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Review
  4. Article
  5. Article
  6. A Compensated Clock: Temperature and Nutritional Compensation Mechanisms Across Circadian Systems.BioEssays : news and reviews in molecular, cellular and developmental biology · 2025
    Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Radhika JoshiDepartment of Neurobiology, University of Massachusetts Chan Medical School, Worcester, MA, United States.
Yao D CaiDepartment of Entomology and Nematology, University of California, Davis, Davis, CA, United States.
Yongliang XiaDepartment of Neurobiology, University of Massachusetts Chan Medical School, Worcester, MA, United States.
Joanna C ChiuDepartment of Entomology and Nematology, University of California, Davis, Davis, CA, United States.
Patrick EmeryDepartment of Neurobiology, University of Massachusetts Chan Medical School, Worcester, MA, United States.
University of Massachusetts Chan Medical School · USUniversity of California, Davis · US

Funding

Molecular and neural mechanisms generating and synchronizing circadian rhythmsR35GM118087 · NIGMS · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI EMERY, PATRICK · 2016 to 2020
$4.4M
NIGMS NIH HHS R35 GM118087
6 · The paper itself

Abstract

Ambient temperature varies constantly. However, the period of circadian pacemakers is remarkably stable over a wide-range of ecologically- and physiologically-relevant temperatures, even though the kinetics of most biochemical reactions accelerates as temperature rises. This thermal buffering phenomenon, called temperature compensation, is a critical feature of circadian rhythms, but how it is achieved remains elusive. Here, we uncovered the important role played by the

Indexed as

circadian rhythmsdrosophilaperiodphophorylated amino acidstemperature compensation

Identifiers

PMID35721569
PMCPMC9201207
OpenAlexW4281616435

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.