Evidence map›Paper›PMID 35721519›Full record

ArticleFrontiers in cell and developmental biology2022

In Depth Exploration of the Alternative Proteome of

Bertrand Fabre, Sebastien A Choteau, Carine Duboé, Carole Pichereaux, Audrey Montigny, Dagmara Korona, Michael J Deery, Mylène Camus, Christine Brun, Odile Burlet-Schiltz and 4 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in cell and developmental biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.0field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Identification of Canonical and Alternative Proteins by Mass Spectrometry.Methods in molecular biology (Clifton, N.J.) · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 7 institutions in 2 countries.

Bertrand FabreLaboratoire de Recherche en Sciences Végétales, UMR5546, Université de Toulouse, UPS, INP, CNRS, Auzeville-Tolosane, France.
Sebastien A ChoteauAix-Marseille Université, INSERM, TAGC, Turing Centre for Living Systems, Marseille, France.
Carine DuboéLaboratoire de Recherche en Sciences Végétales, UMR5546, Université de Toulouse, UPS, INP, CNRS, Auzeville-Tolosane, France.
Carole PichereauxFédération de Recherche (FR3450), Agrobiosciences, Interactions et Biodiversité (AIB), CNRS, Toulouse, France.
Audrey MontignyLaboratoire de Recherche en Sciences Végétales, UMR5546, Université de Toulouse, UPS, INP, CNRS, Auzeville-Tolosane, France.
Dagmara KoronaCambridge Systems Biology Centre and Department of Genetics, University of Cambridge, Cambridge, United Kingdom.
Michael J DeeryCambridge Centre for Proteomics, Cambridge Systems Biology Centre and Department of Biochemistry, University of Cambridge, Cambridge, United Kingdom.
Mylène CamusInstitut de Pharmacologie et de Biologie Structurale (IPBS), Université de Toulouse, CNRS, UPS, Toulouse, France.
Christine BrunAix-Marseille Université, INSERM, TAGC, Turing Centre for Living Systems, Marseille, France.
Odile Burlet-SchiltzInstitut de Pharmacologie et de Biologie Structurale (IPBS), Université de Toulouse, CNRS, UPS, Toulouse, France.
Steven RussellCambridge Systems Biology Centre and Department of Genetics, University of Cambridge, Cambridge, United Kingdom.
Jean-Philippe CombierLaboratoire de Recherche en Sciences Végétales, UMR5546, Université de Toulouse, UPS, INP, CNRS, Auzeville-Tolosane, France.
Kathryn S LilleyCambridge Centre for Proteomics, Cambridge Systems Biology Centre and Department of Biochemistry, University of Cambridge, Cambridge, United Kingdom.
Serge PlazaLaboratoire de Recherche en Sciences Végétales, UMR5546, Université de Toulouse, UPS, INP, CNRS, Auzeville-Tolosane, France.
University of Cambridge · GBLaboratoire de Recherche en Sciences Végétales · FRAix-Marseille Université · FRUniversité Fédérale de Toulouse Midi-Pyrénées · FRInstitut de Pharmacologie et de Biologie Structurale · FRInstitut National Polytechnique de Toulouse · FRUniversité Toulouse III - Paul Sabatier · FR

Funding

Biotechnology and Biological Sciences Research Council BB/L002817/1
6 · The paper itself

Abstract

Recent studies have shown that hundreds of small proteins were occulted when protein-coding genes were annotated. These proteins, called alternative proteins, have failed to be annotated notably due to the short length of their open reading frame (less than 100 codons) or the enforced rule establishing that messenger RNAs (mRNAs) are monocistronic. Several alternative proteins were shown to be biologically active molecules and seem to be involved in a wide range of biological functions. However, genome-wide exploration of the alternative proteome is still limited to a few species. In the present article, we describe a deep peptidomics workflow which enabled the identification of 401 alternative proteins in

Indexed as

alternative proteinsmass spectrometrymicroproteinpeptidomicsshort open reading frame–encoded polypeptide

Identifiers

PMID35721519
PMCPMC9204603
OpenAlexW4281760484

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.