Evidence map›Paper›PMID 35721459›Full record

ArticleTransplantation direct2022

Nonutilization of Kidneys From Donors After Circulatory Determinant of Death.

Yingxin Lin, Armando Teixeira-Pinto, Helen Opdam, Jeremy R Chapman, Jonathan C Craig, Natasha Rogers, Henry Pleass, Christopher Davies, Stephen McDonald, Jean Yang and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Transplantation direct, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
1.3field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 7 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 7 institutions in 1 country.

Yingxin LinSydney School of Public Health, University of Sydney, Sydney, Australia.
Armando Teixeira-PintoSydney School of Public Health, University of Sydney, Sydney, Australia.
Helen OpdamDonateLife, Organ and Tissue Authority, Canberra, Australia.
Jeremy R ChapmanCentre for Transplant and Renal Research, Westmead Hospital, Sydney, Australia.
Jonathan C CraigCollege of Medicine and Public Health, Flinders University, Bedford Park, Australia.
Natasha RogersCentre for Transplant and Renal Research, Westmead Hospital, Sydney, Australia.
Henry PleassSpecialty of Surgery, University of Sydney, Sydney, Australia.
Christopher DaviesAustralia and New Zealand Dialysis and Transplant Registry, South Australian Health and Medical Research Institute, Adelaide, Australia.
Stephen McDonaldAustralia and New Zealand Dialysis and Transplant Registry, South Australian Health and Medical Research Institute, Adelaide, Australia.
Jean YangFaculty of Science, School of Mathematics and Science, University of Sydney, Sydney, Australia.
Wai LimMedical School, University of Western Australia, Perth, Australia.
Germaine WongSydney School of Public Health, University of Sydney, Sydney, Australia.
The University of Sydney · AUAustralia and New Zealand Dialysis and Transplant Registry · AUWestmead Hospital · AUChildren's Hospital at Westmead · AUFlinders University · AUOrgan and Tissue Authority · AUThe University of Western Australia · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: The expansion of donation after circulatory determination of death (DCDD) programs and unmet demands for kidney transplantation indicate that there is a need to improve the efficiency and utilization of these organs. Methods: We studied all DCDD donors retrieved for kidney transplantation in Australia between 2014 and 2019 and determined the factors associated with nonutilization using least absolute shrinkage and selection operator and random forest models. Self-organizing maps were used to group these donors into clusters with similar characteristics and features associated with nonutilization were defined. Results: Of the 762 DCDD donors, 116 (15%) were not utilized for kidney transplantation. Of the 9 clusters derived from self-organizing map, 2 had the highest proportions of nonutilized kidneys. Factors for nonutilization (adjusted odds ratio [95% confidence interval], per SD increase) were duration from withdrawal of cardiorespiratory support till death (1.38 [1.16-1.64]), admission and terminal serum creatinine (1.43 [1.13-1.85]) and (1.41 [1.16-1.73]). Donor kidney function and duration of warm ischemia were the main factors for clinical decisions taken not to use kidneys from DCDD donors. Conclusions: Donor terminal kidney function and the duration of warm ischemia are the key factors for nonutilization of DCDD kidneys. Strategies to reduce the duration of warm ischemia and improve post-transplant recipient kidney function may reduce rates of nonutilization.

Identifiers

PMID35721459
PMCPMC9197368
OpenAlexW4280559671

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.