ArticleFrontiers in human neuroscience2022
Current Steering Using Multiple Independent Current Control Deep Brain Stimulation Technology Results in Distinct Neurophysiological Responses in Parkinson's Disease Patients.
Article in Frontiers in human neuroscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed, 9 citations in OpenAlex.
- Clinical utility of evoked potentials for programming subthalamic deep brain stimulation in Parkinsons disease.NPJ Parkinson's disease · 2026Review
- EEG-based biomarkers for optimizing deep brain stimulation contact configuration in Parkinson's disease.Frontiers in neuroscience · 2023Article
- Towards biomarker-based optimization of deep brain stimulation in Parkinson's disease patients.Frontiers in neuroscience · 2022Article
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Deep brain stimulation (DBS) is an effective neuromodulation therapy to treat people with medication-refractory Parkinson's disease (PD). However, the neural networks affected by DBS are not yet fully understood. Recent studies show that stimulating on different DBS-contacts using a single current source results in distinct EEG-based evoked potentials (EPs), with a peak at 3 ms (P3) associated with dorsolateral subthalamic nucleus stimulation and a peak at 10 ms associated with substantia nigra stimulation. Multiple independent current control (MICC) technology allows the center of the electric field to be moved in between two adjacent DBS-contacts, offering a potential advantage in spatial precision. Objective: Determine if MICC precision targeting results in distinct neurophysiological responses recorded Materials and Methods: We recorded cortical EPs in five hemispheres (four PD patients) using EEG whilst employing MICC to move the electric field from the most dorsal DBS-contact to the most ventral in 15 incremental steps. Results: The center of the electric field location had a significant effect on both the P3 and P10 amplitude in all hemispheres where a peak was detected (P3, detected in 4 of 5 hemispheres, Conclusion: Using MICC to incrementally move the center of the electric field to locations between adjacent DBS-contacts resulted in significantly different neurophysiological responses that may allow further precision of the programming of individual patients.
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Registered trials
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