ArticleWorld journal of hepatology2022
Dietary phytochemical consumption is inversely associated with liver alkaline phosphatase in Middle Eastern adults.
Article in World journal of hepatology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed, 2 citations in OpenAlex.
- The association of dietary phytochemical index and nonalcoholic fatty liver disease.Food science & nutrition · 2023Article
- Dietary antioxidants and liver enzymes in Rafsanjan, a Region in Southeast Iran.Scientific reports · 2023Article
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Authors and funding
7 authors at 2 institutions in 2 countries.
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Abstract
backgroundThe hepatoprotective effects of phytochemicals are controversial. A dietary phytochemical index (DPI) has been suggested as an alternative method for quantifying the phytochemical content of foods.
aimTo assess the DPI in relation to liver function tests among a representative sample of Iranian adults.
methodsA total of 5111 participants aged 35-70 years old were included in this cross-sectional study by a multistage cluster random sampling method. Dietary intakes were collected by a validated and reliable food frequency questionnaire with 121 items. DPI was calculated by the percent of daily energy intake taken from phytochemical-rich foods. Fasting serum concentrations of alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP) and gamma glutamyl transferase (GGT) were determined. Linear regression was used to investigate the association between DPI and levels of liver enzymes using crude and adjusted models.
resultsThere was an inverse association between DPI score and serum ALP in the crude model (β = -0.05;
conclusionHigher adherence to phytochemical-rich foods was associated with lower levels of ALP, but no change in other liver enzymes. Those with higher DPI scores also consumed food items associated with a healthier overall dietary pattern; however, they also presented several unexpected metabolic derangements. Additional randomised trials are needed to better determine the effects of phytochemical-rich foods on liver function.
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