Evidence map›Paper›PMID 35721271›Full record

ArticleInternational journal of nanomedicine2022

Riclin-Capped Silver Nanoparticles as an Antibacterial and Anti-Inflammatory Wound Dressing.

Changchang Kong, Shijunyin Chen, Wenhao Ge, Yang Zhao, Xiaodong Xu, Shiming Wang, Jianfa Zhang

Open access · goldAbstract read
In one paragraph

Article in International journal of nanomedicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
3.7field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 38 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. Review
  12. Review
  13. Review
  14. Article
  15. Review
  16. Article
  17. Review
  18. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Changchang KongCenter for Molecular Metabolism, Nanjing University of Science & Technology, Nanjing, Jiangsu, 210094, People's Republic of China.
Shijunyin ChenCenter for Molecular Metabolism, Nanjing University of Science & Technology, Nanjing, Jiangsu, 210094, People's Republic of China.
Wenhao GeCenter for Molecular Metabolism, Nanjing University of Science & Technology, Nanjing, Jiangsu, 210094, People's Republic of China.
Yang ZhaoCenter for Molecular Metabolism, Nanjing University of Science & Technology, Nanjing, Jiangsu, 210094, People's Republic of China.
Xiaodong XuCenter for Molecular Metabolism, Nanjing University of Science & Technology, Nanjing, Jiangsu, 210094, People's Republic of China.
Shiming WangCenter for Molecular Metabolism, Nanjing University of Science & Technology, Nanjing, Jiangsu, 210094, People's Republic of China.
Jianfa ZhangCenter for Molecular Metabolism, Nanjing University of Science & Technology, Nanjing, Jiangsu, 210094, People's Republic of China.ORCID 0000-0002-8814-9103
Nanjing University of Science and Technology · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Purpose: In order to overcome the inflammatory response to bacterial infection during wound healing, we have fabricated an antibacterial and anti-inflammatory wound dressing based on polysaccharide riclin and silver nanoparticles (AgNPs). Methods: The riclin-AgNPs nanocomposite was developed by borohydride method and was characterized by UV-Vis, TEM, XRD, Zeta potential, DLS. In vitro, we assessed the cumulative release, antibacterial activities and cytotoxicity. In vivo, we examined the wound healing in mice wound infection experiment and inflammatory mediators using histological observations and gene expression analysis. Results: The riclin/AgNPs nanocomposite hydrogel exhibited nanosized orbicular particles with high purity and stability. In vitro, the riclin/AgNPs showed sustained release of AgNPs, effective suppression in pathogen growth and negligible toxicity toward mammalian fibroblasts and macrophage cells. In vivo, the riclin/AgNPs treatment leads to faster and smoother growth of fresh skin with suppressed expression of inflammatory mediators. Conclusion: The reported Riclin-AgNPs nanocomposite hydrogel showed both antibacterial and anti-inflammatory functions, which induce significantly accelerated wound healing, indicating great potential as a novel attractive wound dressing material.

Indexed as

Metal NanoparticlesSilverAnimalsAnti-Bacterial AgentsAnti-Inflammatory AgentsBandagesInflammation MediatorsMammalsMiceMicrobial Sensitivity TestsNanogelsAnti-Bacterial AgentsAnti-Inflammatory AgentsInflammation MediatorsNanogelsSilvernanocomposite hydrogelsriclinsilver nanoparticleswound healing

Identifiers

PMID35721271
PMCPMC9205441
OpenAlexW4283065845

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.