Evidence map›Paper›PMID 35721241›Full record

ArticleWorld journal of methodology2022

Global prevalence of occult hepatitis C virus: A systematic review and meta-analysis.

Donatien Serge Mbaga, Sebastien Kenmoe, Jacky Njiki Bikoï, Guy Roussel Takuissu, Marie Amougou-Atsama, Etienne Atenguena Okobalemba, Jean Thierry Ebogo-Belobo, Arnol Bowo-Ngandji, Martin Gael Oyono, Jeannette Nina Magoudjou-Pekam and 18 more

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in World journal of methodology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
1.1field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 9 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

28 authors at 3 institutions in 1 country.

Donatien Serge MbagaDepartment of Microbiology, The University of Yaounde I, Yaounde 00237, Cameroon.
Sebastien KenmoeDepartment of Microbiology and Parasitology, University of Buea, Buea 00237, Cameroon.
Jacky Njiki BikoïDepartment of Microbiology, The University of Yaounde I, Yaounde 00237, Cameroon.
Guy Roussel TakuissuCentre of Research in Food, Food Security and Nutrition, Institute of Medical Research and Medicinal Plants Studies, Yaounde 00237, Cameroon.
Marie Amougou-AtsamaCentre de Recherche sur les Maladies Emergentes et Re-Emergentes, Institute of Medical Research and Medicinal Plants Studies, Yaounde 00237, Cameroon.
Etienne Atenguena OkobalembaFaculty of Medicine and Biomedical Science, The University of Yaounde I, Yaounde 00237, Cameroon.
Jean Thierry Ebogo-BeloboMedical Research Centre, Institute of Medical Research and Medicinal Plants Studies, Yaounde 00237, Cameroon.
Arnol Bowo-NgandjiDepartment of Microbiology, The University of Yaounde I, Yaounde 00237, Cameroon.
Martin Gael OyonoLaboratory of Parasitology and Ecology, The University of Yaounde I, Yaounde 00237, Cameroon.
Jeannette Nina Magoudjou-PekamDepartment of Biochemistry, The University of Yaounde I, Yaounde 00237, Cameroon.
Ginette Irma Kame-NgasseMedical Research Centre, Institute of Medical Research and Medicinal Plants Studies, Yaounde 00237, Cameroon.
Alex Durand NkaVirology Laboratory, Chantal Biya International Reference Center for Research on HIV/AIDS Prevention and Management, Yaounde 00237, Cameroon.
Alfloditte Flore FeudjioDepartment of Biochemistry, The University of Yaounde I, Yaounde 00237, Cameroon.
Cromwel Zemnou-TepapDepartment of Biochemistry, The University of Yaounde I, Yaounde 00237, Cameroon.
Elie Adamou VelhimaMedical Research Centre, Institute of Medical Research and Medicinal Plants Studies, Yaounde 00237, Cameroon.
Juliette Laure Ndzie OndiguiDepartment of Microbiology, The University of Yaounde I, Yaounde 00237, Cameroon.
Rachel Audrey Nayang-MundoDepartment of Microbiology, Protestant University of Central Africa, Yaounde 00237, Cameroon.
Sabine Aimee Touangnou-ChamdaDepartment of Microbiology, The University of Yaounde I, Yaounde 00237, Cameroon.
Yrene Kamtchueng TakeuMedical Research Centre, Institute of Medical Research and Medicinal Plants Studies, Yaounde 00237, Cameroon.
Jean Bosco Taya-FokouDepartment of Microbiology, The University of Yaounde I, Yaounde 00237, Cameroon.
Chris Andre Mbongue MikangueDepartment of Microbiology, The University of Yaounde I, Yaounde 00237, Cameroon.
Raoul Kenfack-MomoDepartment of Biochemistry, The University of Yaounde I, Yaounde 00237, Cameroon.
Cyprien Kengne-NdéEpidemiological Surveillance, Evaluation and Research Unit, National Aids Control Committee, Douala 00237, Cameroon.
Carole Stephanie SakeDepartment of Microbiology, The University of Yaounde I, Yaounde 00237, Cameroon.
Seraphine Nkie EsemuDepartment of Microbiology and Parasitology, University of Buea, Buea 00237, Cameroon.
Richard NjouomDepartment of Virology, Centre Pasteur of Cameroon, Yaounde 00237, Cameroon.
Lucy NdipDepartment of Microbiology and Parasitology, University of Buea, Buea 00237, Cameroon.
Sara Honorine Riwom EssamaDepartment of Microbiology, The University of Yaounde I, Yaounde 00237, Cameroon.
Université de Yaoundé I · CMMinistry of Scientific Research and Innovation · CMUniversity of Buea · CM

Funding

European & Developing Countries Clinical Trials Partnership (EDCTP) TMA2019PF-2705
6 · The paper itself

Abstract

backgroundOccult hepatitis C infection (OCI) is characterized by the presence of hepatitis C virus (HCV) RNA in the liver, peripheral blood mononuclear cells (PBMC) and/or ultracentrifuged serum in the absence of detectable HCV-RNA in serum. OCI has been described in several categories of populations including hemodialysis patients, patients with a sustained virological response, immunocompromised individuals, patients with abnormal hepatic function, and apparently healthy subjects.

aimTo highlight the global prevalence of OCI.

methodsWe performed a systematic and comprehensive literature search in the following 4 electronic databases PubMed, EMBASE, Global Index Medicus, and Web of Science up to 6th May 2021 to retrieve relevant studies published in the field. Included studies were unrestricted population categories with known RNA status in serum, PBMC, liver tissue and/or ultracentrifuged serum. Data were extracted independently by each author and the Hoy

resultsThe electronic search resulted in 3950 articles. We obtained 102 prevalence data from 85 included studies. The pooled prevalence of seronegative OCI was estimated to be 9.61% (95%CI: 6.84-12.73) with substantial heterogeneity [

conclusionIn conclusion, in the present study, it appears that the burden of OCI is high and variable across the different regions and population categories. Further studies on OCI are needed to assess the transmissibility, clinical significance, long-term outcome, and need for treatment.

Indexed as

Hepatitis C virusOccult hepatitis C virus infectionPeripheral blood mononuclear cellsPrevalenceWorldwide

Identifiers

PMID35721241
PMCPMC9157636
OpenAlexW4280599271

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.