ArticleFrontiers in computational neuroscience2022
Treatment Enhances Betweenness Centrality of Fronto-Parietal Network in Parkinson's Patients.
Article in Frontiers in computational neuroscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Quantifying Similarity of Dynamic Brain Networks: Two Novel Indices for Structural Change and Temporal Evolution.Bioengineering (Basel, Switzerland) · 2025Article
- Large-scale functional network connectivity mediates the association between nigral neuromelanin hypopigmentation and motor impairment in Parkinson's disease.Brain structure & function · 2024Article
- Abnormal Topological Organization of White Matter Structural Networks in Normal Tension Glaucoma Revealed via Diffusion Tensor Tractography.Brain sciences · 2023Article
- Extra-Basal Ganglia Brain Structures Are Related to Motor Reserve in Parkinson's Disease.Journal of Parkinson's disease · 2023Article
- Structural connectivity and brain network analyses in Parkinson's disease: A cross-sectional and longitudinal study.Frontiers in neurology · 2023Article
- Alterations of Regional Homogeneity in Parkinson's Disease with Rapid Eye Movement Sleep Behavior Disorder.Neuropsychiatric disease and treatment · 2022Article
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Authors and funding
7 authors.
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Abstract
Previous studies have demonstrated a close relationship between early Parkinson's disease and functional network abnormalities. However, the pattern of brain changes in the early stages of Parkinson's disease has not been confirmed, which has important implications for the study of clinical indicators of Parkinson's disease. Therefore, we investigated the functional connectivity before and after treatment in patients with early Parkinson's disease, and further investigated the relationship between some topological properties and clinicopathological indicators. We included resting state-fMRI (rs-fMRI) data from 27 patients with early Parkinson's disease aged 50-75 years from the Parkinson's Disease Progression Markers Initiative (PPMI). The results showed that the functional connectivity of 6 networks, cerebellum network (CBN), cingulo_opercular network (CON), default network (DMN), fronto-parietal network (FPN), occipital network (OCC), and sensorimotor network (SMN), was significantly changed. Compared to before treatment, the main functional connections were concentrated in the CBN after treatment. In addition, the coefficients of these nodes have also changed. For betweenness centrality (BC), the FPN showed a significant improvement in treatment (
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