ArticleFrontiers in neuroscience2022
Dynamic Changes of Brain Activity in Patients With Disorders of Consciousness During Recovery of Consciousness.
Article in Frontiers in neuroscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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14 citing papers in PubMed, 22 citations in OpenAlex.
- Prognosis prediction of patients with disorders of consciousness based on digital twin brain models.Journal of neuroengineering and rehabilitation · 2026Article
- Development of an exploratory mismatch negativity-based prognostic nomogram for consciousness recovery in patients with prolonged disorders of consciousness: a derivation study.BMC neurology · 2025Article
- EEG Microstates During Multisensory Stimulation: Assessing the Severity of Disorders of Consciousness and Distinguishing the Minimally Conscious State.Brain sciences · 2025Article
- Characterizing consciousness states: EEG microstate dynamics in patients with disorders of consciousness during naturalistic movie-viewing.Medical & biological engineering & computing · 2025Article
- Evaluating Brain Activity in Patients With Chronic Disorders of Consciousness After Traumatic Brain Injury Using EEG Microstate Analysis During Hyperbaric Oxygen Therapy.CNS neuroscience & therapeutics · 2025Article
- Effect of topographic comparison of electroencephalographic microstates on the diagnosis and prognosis prediction of patients with prolonged disorders of consciousness.CNS neuroscience & therapeutics · 2024Article
- Establishment and validation of a bad outcomes prediction model based on EEG and clinical parameters in prolonged disorder of consciousness.Frontiers in human neuroscience · 2024Article
- Use of magnetic source imaging to assess recovery after severe traumatic brain injury-an MEG pilot study.Frontiers in neurology · 2023Article
- EEG spectral and microstate analysis originating residual inhibition of tinnitus induced by tailor-made notched music training.Frontiers in neuroscience · 2023Article
- EEG microstate changes during hyperbaric oxygen therapy in patients with chronic disorders of consciousness.Frontiers in neuroscience · 2023Article
- Effects of simultaneous transcutaneous auricular vagus nerve stimulation and high-definition transcranial direct current stimulation on disorders of consciousness: a study protocol.Frontiers in neurology · 2023Article
- Resting-state EEG microstates as electrophysiological biomarkers in post-stroke disorder of consciousness.Frontiers in neuroscience · 2023Article
- Transcutaneous auricular vagus nerve stimulation in the treatment of disorders of consciousness: mechanisms and applications.Frontiers in neuroscience · 2023Review
- Dynamic Changes of Brain Activity in Different Responsive Groups of Patients with Prolonged Disorders of Consciousness.Brain sciences · 2022Article
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9 authors at 3 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
The disorder of brain activity dynamics is one of the main characteristics leading to disorders of consciousness (DOC). However, few studies have explored whether the dynamics of brain activity can be modulated, and whether the dynamics of brain activity can help to evaluate the state of consciousness and the recovery progress of consciousness. In current study, 20 patients with minimally conscious state (MCS) and 13 patients with vegetative state (VS) were enrolled, and resting state electroencephalogram (EEG) data and the coma recovery scale-revised (CRS-R) scores were collected three times before and after high-definition transcranial direct current stimulation (HD-tDCS) treatment. The patients were divided into the improved group and the unimproved group according to whether the CRS-R scores were improved after the treatment, and the dynamic changes of resting state EEG microstate parameters during treatment were analyzed. The results showed the occurrence per second (OPS) of microstate D was significantly different between the MCS group and VS group, and it was positively correlated with the CRS-R before the treatment. After 2 weeks of the treatment, the OPS of microstate D improved significantly in the improved group. Meanwhile, the mean microstate duration (MMD), ratio of time coverage (Cov) of microstate C and the Cov of microstate D were significantly changed after the treatment. Compared with the microstates parameters before the treatment, the dynamic changes of parameters with significant difference in the improved group showed a consistent trend after the treatment. In contrast, the microstates parameters did not change significantly after the treatment in the unimproved group. The results suggest that the dynamics of EEG brain activity can be modulated by HD-tDCS, and the improvement in brain activity dynamics is closely related to the recovery of DOC, which is helpful to evaluate the level of DOC and the progress of recovery of consciousness.
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