Evidence map›Paper›PMID 35720640›Full record

ArticleNeurobiology of pain (Cambridge, Mass.)

Interplay between exosomes and autophagy machinery in pain management: State of the art.

Hamidreza Morteza Bagi, Sajjad Ahmadi, Faezeh Tarighat, Reza Rahbarghazi, Hassan Soleimanpour

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurobiology of pain (Cambridge, Mass.). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it, 19 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Review
  8. Review
  9. Protein corona and exosomes: new challenges and prospects.Cell communication and signaling : CCS · 2023
    Review
  10. Neuropathic pain; what we know and what we should do about it.Frontiers in pain research (Lausanne, Switzerland) · 2023
    Review
  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Hamidreza Morteza BagiEmergency and Trauma Care Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Sajjad AhmadiEmergency and Trauma Care Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Faezeh TarighatEmergency and Trauma Care Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Reza RahbarghaziStem Cell Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Hassan SoleimanpourRoad Traffic Injury Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Tabriz University of Medical Sciences · IR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Despite recent progress regarding inexpensive medical approaches, many individuals suffer from moderate to severe pain globally. The discovery and advent of exosomes, as biological nano-sized vesicles, has revolutionized current knowledge about underlying mechanisms associated with several pathological conditions. Indeed, these particles are touted as biological bio-shuttles with the potential to carry specific signaling biomolecules to cells in proximity and remote sites, maintaining cell-to-cell communication in a paracrine manner. A piece of evidence points to an intricate relationship between exosome biogenesis and autophagy signaling pathways at different molecular levels. A close collaboration of autophagic response with exosome release can affect the body's hemostasis and physiology of different cell types. This review is a preliminary attempt to highlight the possible interface of autophagy flux and exosome biogenesis on pain management with a special focus on neuropathic pain. It is thought that this review article will help us to understand the interplay of autophagic response and exosome biogenesis in the management of pain under pathological conditions. The application of therapies targeting autophagy pathway and exosome abscission can be an alternative strategy in the regulation of pain.

Indexed as

AutophagyCell TherapyCESC-Exo, cartilage endplate stem cell-derived ExoER, endoplasmic reticulumESCRT, endosomal sorting complex required for transportHSPA8, heat shock protein family A member 8LAMP2, lysosomal‑associated membrane protein type 2LAT1, large amino acid transporterLTs, leukotrienesMAPK8/JNK, mitogen-activated protein kinase 8p-/c-Jun N-terminal KinaseMMP, matrix metalloproteinaseMVBs, multivesicular bodiesNeural ExosomeNFKB/NF-κB, nuclear factor of kappa light polypeptide gene enhancer in B cellsNPCs-Exo, NPCs-derived ExoNPCs, nucleus pulposus cellsnSMase, ceramide-generating enzyme neutral sphingomyelinasesPain ManagementSNARE, soluble N-ethylmaleimide-sensitive factor attachment protein receptorsTLR4, Toll-like receptor 4TRAF6, TNF receptor-associated factor 6

Identifiers

PMID35720640
PMCPMC9198378
OpenAlexW4281687624

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.