Evidence map›Paper›PMID 35720615›Full record

ArticleComputational and structural biotechnology journal2022

Maturation of the SARS-CoV-2 virus is regulated by dimerization of its main protease.

Shreyas Kaptan, Mykhailo Girych, Giray Enkavi, Waldemar Kulig, Vivek Sharma, Joni Vuorio, Tomasz Rog, Ilpo Vattulainen

Open access · goldAbstract read
In one paragraph

Article in Computational and structural biotechnology journal, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.2field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. The SARS-CoV-2 MACS synthetic biology · 2024
    Article
  7. A potential allosteric inhibitor of SARS-CoV-2 main protease (MFrontiers in molecular biosciences · 2024
    Article
  8. Machine learning and protein allostery.Trends in biochemical sciences · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Shreyas KaptanDepartment of Physics, University of Helsinki, Helsinki, Finland.
Mykhailo GirychDepartment of Physics, University of Helsinki, Helsinki, Finland.
Giray EnkaviDepartment of Physics, University of Helsinki, Helsinki, Finland.
Waldemar KuligDepartment of Physics, University of Helsinki, Helsinki, Finland.
Vivek SharmaDepartment of Physics, University of Helsinki, Helsinki, Finland.
Joni VuorioDepartment of Physics, University of Helsinki, Helsinki, Finland.
Tomasz RogDepartment of Physics, University of Helsinki, Helsinki, Finland.
Ilpo VattulainenDepartment of Physics, University of Helsinki, Helsinki, Finland.
University of Helsinki · FI

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

SARS-CoV-2 main protease (M

Indexed as

BiophysicsCoronavirusMachine learningMolecular dynamics simulation

Identifiers

PMID35720615
PMCPMC9195460
OpenAlexW4282823425

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.