Evidence map›Paper›PMID 35720381›Full record

ArticleFrontiers in immunology2022

Modification of Extracellular Matrix by the Product of DHA Oxidation Switches Macrophage Adhesion Patterns and Promotes Retention of Macrophages During Chronic Inflammation.

Jared L Casteel, Kasey R Keever, Christopher L Ardell, David L Williams, Detao Gao, Eugene A Podrez, Tatiana V Byzova, Valentin P Yakubenko

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.4field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Jared L CasteelDepartment of Biomedical Sciences, Quillen College of Medicine, East Tennessee State University, Johnson City, TN, United States.
Kasey R KeeverDepartment of Biomedical Sciences, Quillen College of Medicine, East Tennessee State University, Johnson City, TN, United States.
Christopher L ArdellDepartment of Biomedical Sciences, Quillen College of Medicine, East Tennessee State University, Johnson City, TN, United States.
David L WilliamsCenter of Excellence in Inflammation, Infectious Disease and Immunity, Quillen College of Medicine, East Tennessee State University, Johnson City, TN, United States.
Detao GaoDepartment of Inflammation and Immunity, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, United States.
Eugene A PodrezDepartment of Inflammation and Immunity, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, United States.
Tatiana V ByzovaDepartment of Neurosciences, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, United States.
Valentin P YakubenkoDepartment of Biomedical Sciences, Quillen College of Medicine, East Tennessee State University, Johnson City, TN, United States.
East Tennessee State University · USCleveland Clinic Lerner College of Medicine · US

Funding

Regulation of Integrins in Neovasculature DevelopmentR01HL071625 · NHLBI · CLEVELAND CLINIC LERNER COM-CWRU · PI BYZOVA, TATIANA V · 2003 to 2021
$7.3M
Training Innate Immunity: A new approach to the treatment of SepsisR01GM119197 · NIGMS · EAST TENNESSEE STATE UNIVERSITY · PI SHERWOOD, EDWARD R, WILLIAMS, DAVID L. · 2016 to 2024
$4.6M
Innate Immunity and Cardiovascular Function in SepsisR01GM083016 · NIGMS · EAST TENNESSEE STATE UNIVERSITY · PI LI, CHUANFU, WILLIAMS, DAVID L. · 2009 to 2021
$3.8M
Platelets in CancerR01HL142772 · NHLBI · CLEVELAND CLINIC LERNER COM-CWRU · PI BYZOVA, TATIANA V · 2018 to 2021
$2.6M
Role of TLR2 in angiogenesisR01HL145536 · NHLBI · CLEVELAND CLINIC LERNER COM-CWRU · PI BYZOVA, TATIANA V · 2019 to 2022
$2.6M
Novel oxidative pathway targets microglia in Alzheimer's diseaseR01AG082382 · NIA · CLEVELAND CLINIC LERNER COM-CWRU · PI Tatiana V Byzova, EUGENE A PODREZ · 2024 to 2026
$2.3M
The Role of Neuro-Immune Synapse in Macrophage MigrationR15HL157836 · NHLBI · EAST TENNESSEE STATE UNIVERSITY · PI YAKUBENKO, VALENTIN P · 2022 to 2024
$484k
NHLBI NIH HHS R01 HL071625NHLBI NIH HHS R01 HL142772NHLBI NIH HHS R01 HL145536NHLBI NIH HHS R15 HL157836NIA NIH HHS R01 AG082382NIGMS NIH HHS R01 GM083016NIGMS NIH HHS R01 GM119197
6 · The paper itself

Abstract

Oxidation of polyunsaturated fatty acids contributes to different aspects of the inflammatory response due to the variety of products generated. Specifically, the oxidation of DHA produces the end-product, carboxyethylpyrrole (CEP), which forms a covalent adduct with proteins

Indexed as

LamininMacrophagesAnimalsCollagenExtracellular MatrixFibrinogenHEK293 CellsHumansInflammationIntegrinsLigandsMiceCollagenFibrinogenIntegrinsLamininLigandsadhesioncarboxyethylpyrrole (CEP)CD11d/CD18ECMinflammationintegrin αDβ2macrophagemigration

Identifiers

PMID35720381
PMCPMC9204313
OpenAlexW4281757404

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.