Evidence map›Paper›PMID 35720352›Full record

ReviewFrontiers in immunology2022

Novel Immune-Based treatments for Diffuse Large B-Cell Lymphoma: The Post-CAR T Cell Era.

Suheil Albert Atallah-Yunes, Michael J Robertson, Utpal P Davé, Paola Ghione, Fabiana Perna

Open access · goldAbstract readReview
In one paragraph

Review in Frontiers in immunology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.0field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 10 citations in OpenAlex.

  1. Trial
  2. Review
  3. Article
  4. Review
  5. Design and synthesis of novelFuture medicinal chemistry · 2025
    Article
  6. Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Suheil Albert Atallah-YunesDepartment of Medicine, Division of Hematology/Oncology, Indiana University School of Medicine, Indianapolis, IN, United States.
Michael J RobertsonDepartment of Medicine, Division of Hematology/Oncology, Indiana University School of Medicine, Indianapolis, IN, United States.
Utpal P DavéDepartment of Medicine, Division of Hematology/Oncology, Indiana University School of Medicine, Indianapolis, IN, United States.
Paola GhioneLymphoma and Myeloma Program, Roswell Park Comprehensive Cancer Center, Buffalo, NY, United States.
Fabiana PernaDepartment of Medicine, Division of Hematology/Oncology, Indiana University School of Medicine, Indianapolis, IN, United States.
Indiana University School of MedicineRichard L. Roudebush VA Medical Center · USRoswell Park Comprehensive Cancer Center · US

Funding

Viral Vector Technology (VVTSR)P30CA021765 · NCI · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI Shondra Michelle Miller · 1985 to 2026
$166.9M
The Role of LMO2 in the Pathogenesis of T-cell LeukemiaR01CA207530 · NCI · INDIANA UNIVERSITY INDIANAPOLIS · PI DAVE, UTPAL P · 2016 to 2020
$1.8M
BLRD VA I01 BX001799NCI NIH HHS P30 CA021765NCI NIH HHS R01 CA207530
6 · The paper itself

Abstract

Prognosis for patients with refractory/relapsed (R/R) diffuse large B-cell lymphoma (DLBCL) is poor. Immune-based therapeutic treatments such as CD19 Chimeric Antigen Receptor (CAR) T cell therapies have dramatically changed the treatment landscape for R/R DLBCL leading to durable remissions in ~ 50% of patients. However, there remains an unmet need for developing novel therapies to improve clinical outcomes of patients not responding or relapsing after CAR T cell therapies. Lack of suitable immunotherapeutic targets and disease heterogeneity represent the foremost challenges in this emerging field. In this review, we discuss the recently approved and emerging novel immunotherapies for patients with R/R DLBCL in the post-CAR T era and the cell surface targets currently used.

Indexed as

Lymphoma, Large B-Cell, DiffuseT-LymphocytesAntigens, CD19HumansImmunotherapy, AdoptiveNeoplasm Recurrence, LocalAntigens, CD19chimeric antigen receptor T-cell therapydiffuse large B-cell lymphomadiscoveryhigh-riskimmunotherapytarget

Identifiers

PMID35720352
PMCPMC9198279
OpenAlexW4281881947

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.