Evidence map›Paper›PMID 35720315›Full record

ArticleFrontiers in immunology2022

Nanoscale Colocalization of NK Cell Activating and Inhibitory Receptors Controls Signal Integration.

David Tomaz, Pedro Matos Pereira, Nadia Guerra, Julian Dyson, Keith Gould, Ricardo Henriques

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.3field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 2 countries.

David TomazDepartment of Immunology, Wright-Fleming Institute, Imperial College London, London, United Kingdom.
Pedro Matos PereiraMedical Research Council Laboratory for Molecular Cell Biology, University College London, London, United Kingdom.
Nadia GuerraDivision of Cell and Molecular Biology, Faculty of Natural Sciences, Imperial College London, London, United Kingdom.
Julian DysonDepartment of Immunology, Hammersmith Hospital, Imperial College London, London, United Kingdom.
Keith GouldDepartment of Immunology, Wright-Fleming Institute, Imperial College London, London, United Kingdom.
Ricardo HenriquesMedical Research Council Laboratory for Molecular Cell Biology, University College London, London, United Kingdom.
Imperial College London · GBHammersmith Hospital · GBInstituto Gulbenkian de Ciência · PTUniversity College London · GB

Funding

Biotechnology and Biological Sciences Research Council BB/M022374/1Biotechnology and Biological Sciences Research Council BB/P027431/1Biotechnology and Biological Sciences Research Council BB/R000697/1Medical Research Council MR/K015826/1Medical Research Council MR/V001256/1Wellcome Trust 088381/Z/09/ZWellcome Trust 203276/Z/16/Z
6 · The paper itself

Abstract

Natural killer (NK) cell responses depend on the balance of signals from inhibitory and activating receptors. However, how the integration of antagonistic signals occurs upon NK cell-target cell interaction is not fully understood. Here we provide evidence that NK cell inhibition

Indexed as

NK Cell Lectin-Like Receptor Subfamily ANK Cell Lectin-Like Receptor Subfamily KAnimalsCarrier ProteinsH-2 AntigensHistocompatibility Antigen H-2DKiller Cells, NaturalLectins, C-TypeLigandsMiceNIH 3T3 CellsReceptors, Natural Killer CellReceptors, NK Cell Lectin-LikeCarrier ProteinsH-2 AntigensHistocompatibility Antigen H-2DLectins, C-TypeLigandsNK Cell Lectin-Like Receptor Subfamily ANK Cell Lectin-Like Receptor Subfamily KReceptors, Natural Killer CellReceptors, NK Cell Lectin-LikeFRETLy49Ananoscale colocalizationNK cell receptors and ligandsNK cell signalingNKG2Dsignal integration

Identifiers

PMID35720315
PMCPMC9198454
OpenAlexW4281721247

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.