Evidence map›Paper›PMID 35720229›Full record

ArticleJournal of clinical medicine research2022

Analysis of Risk Factors of Soft Tissue Bleeding in COVID-19 Patients: A Point of View After Two Years of Pandemic.

Eliodoro Faiella, Gennaro Castiello, Domiziana Santucci, Giuseppina Pacella, Caterina Bernetti, Moises Muley Villamu, Raffaele Antonelli Incalzi, Bruno Beomonte Zobel, Carlo Cosimo Quattrocchi, Rosario Francesco Grasso

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In one paragraph

Article in Journal of clinical medicine research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 50% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Eliodoro FaiellaDepartment of Radiology, Campus Bio-Medico University, Via Alvaro del Portillo, 21-00128 Rome, Italy.
Gennaro CastielloDepartment of Radiology, Campus Bio-Medico University, Via Alvaro del Portillo, 21-00128 Rome, Italy.
Domiziana SantucciDepartment of Radiology, Campus Bio-Medico University, Via Alvaro del Portillo, 21-00128 Rome, Italy.
Giuseppina PacellaDepartment of Radiology, Campus Bio-Medico University, Via Alvaro del Portillo, 21-00128 Rome, Italy.
Caterina BernettiDepartment of Radiology, Campus Bio-Medico University, Via Alvaro del Portillo, 21-00128 Rome, Italy.
Moises Muley VillamuDepartment of Geriatrics, Campus Bio-Medico University, Via Alvaro del Portillo, 21-00128 Rome, Italy.
Raffaele Antonelli IncalziDepartment of Geriatrics, Campus Bio-Medico University, Via Alvaro del Portillo, 21-00128 Rome, Italy.
Bruno Beomonte ZobelDepartment of Radiology, Campus Bio-Medico University, Via Alvaro del Portillo, 21-00128 Rome, Italy.
Carlo Cosimo QuattrocchiDepartment of Radiology, Campus Bio-Medico University, Via Alvaro del Portillo, 21-00128 Rome, Italy.
Rosario Francesco GrassoDepartment of Radiology, Campus Bio-Medico University, Via Alvaro del Portillo, 21-00128 Rome, Italy.
Università Campus Bio-Medico · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: The aim of the study was to analyze the relationship between patient characteristics, including anagraphic and laboratoristic data and amount of adipose tissue measured in computed tomography (CT) scans in coronavirus disease 2019 (COVID-19) patients, and incidence of soft tissue bleeding requiring medical and/or interventional radiology management. Methods: A total of 132 patients hospitalized for COVID-19 pathology from October 2020 to May 2021 were included in the study and divided into two groups: a bleeding group of 70 cases with soft tissue bleeding occurring during hospitalization, and a control group of 62 hospitalized COVID-19 patients without bleeding events. In the bleeding group, two subgroups were considered: an embolization group including soft tissue bleeding cases requiring interventional radiology with transarterial embolization (TAE) (16/70; 22.9%) and a non-embolization group, clinically managed without TAE (54/70; 77.1%). Demographics and clinical data, visceral adipose tissue (VAT) area and subcutaneous adipose tissue (SAT) area measured on CT images and VAT/SAT ratio were compared between bleeding and control groups and between embolization and non-embolization subgroups. Results: Bleeding and control groups did not significantly differ for sex distribution, COVID-19, platelet (PLT) count, international normalized ratio (INR), SAT area, VAT area, and VAT/SAT ratio. Embolization and non-embolization groups did not significantly differ for age, COVID-19, PLT count, INR, SAT area, and VAT/SAT ratio. Bleeding group had lower body mass index (BMI) than control group as well as embolization group compared to non-embolization group. A statistically significant difference was observed between embolization and non-embolization groups for VAT area, with smaller values in embolization group (mean difference: 64.2 cm Conclusion: Soft tissue bleeding in COVID-19 is more frequent and severe in patients with low amount of VAT, demonstrating that fat mass may have a containing function on bleeding, limiting its progression in surrounding structures. There are some other factors that influence the risk of bleeding, such as age, thromboprophylaxis therapy and BMI.

Indexed as

EmbolizationSARS-CoV-2 infectionSoft tissue bleedingVisceral fat

Identifiers

PMID35720229
PMCPMC9187356
OpenAlexW4281729018

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.