Evidence map›Paper›PMID 35720155›Full record

ArticleIJID regions2022

Covishield vaccine induces robust immune responses in Bangladeshi adults.

Taufiqur Rahman Bhuiyan, Marjahan Akhtar, Fatema Khaton, Sadia Isfat Ara Rahman, Jannatul Ferdous, A S M Alamgir, Mahbubur Rahman, Zannat Kawser, Imrul Hasan, Stephen Beaven Calderwood and 7 more

Abstract read
In one paragraph

Article in IJID regions, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Taufiqur Rahman BhuiyanInternational Centre for Diarrhoeal Disease Research Bangladesh, Dhaka, Bangladesh.
Marjahan AkhtarInternational Centre for Diarrhoeal Disease Research Bangladesh, Dhaka, Bangladesh.
Fatema KhatonInternational Centre for Diarrhoeal Disease Research Bangladesh, Dhaka, Bangladesh.
Sadia Isfat Ara RahmanInternational Centre for Diarrhoeal Disease Research Bangladesh, Dhaka, Bangladesh.
Jannatul FerdousInternational Centre for Diarrhoeal Disease Research Bangladesh, Dhaka, Bangladesh.
A S M AlamgirInstitute of Epidemiology, Disease Control and Research, Dhaka, Bangladesh.
Mahbubur RahmanInstitute of Epidemiology, Disease Control and Research, Dhaka, Bangladesh.
Zannat KawserInstitute of Developing Sciences and Health Initiatives, Dhaka, Bangladesh.
Imrul HasanInstitute of Developing Sciences and Health Initiatives, Dhaka, Bangladesh.
Stephen Beaven CalderwoodDivision of Infectious Diseases, Massachusetts General Hospital, Boston, MA, USA.
Jason B HarrisDivision of Infectious Diseases, Massachusetts General Hospital, Boston, MA, USA.
Richelle C CharlesDivision of Infectious Diseases, Massachusetts General Hospital, Boston, MA, USA.
Regina C LaRocqueDivision of Infectious Diseases, Massachusetts General Hospital, Boston, MA, USA.
Edward Thomas RyanDivision of Infectious Diseases, Massachusetts General Hospital, Boston, MA, USA.
Sayera BanuInternational Centre for Diarrhoeal Disease Research Bangladesh, Dhaka, Bangladesh.
Tahmina ShirinInstitute of Epidemiology, Disease Control and Research, Dhaka, Bangladesh.
Firdausi QadriInternational Centre for Diarrhoeal Disease Research Bangladesh, Dhaka, Bangladesh.

Funding

Mucosal associated invariant T (MAIT) cells in Vibrio cholerae infection and vaccinationR01AI130378 · NIAID · UNIVERSITY OF UTAH · PI LEUNG, DANIEL TED · 2017 to 2021
$1.8M
Humoral and adaptive immune responses study in Vibrio cholerae infectionK43TW010362 · FIC · INTERNATIONAL CTR/DIARRHOEAL DIS RES · PI BHUIYAN, MD TAUFIQUR RAHMAN · 2016 to 2020
$359k
FIC NIH HHS K43 TW010362Gates Foundation INV-034303NIAID NIH HHS R01 AI130378
6 · The paper itself

Abstract

Objective: To evaluate severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2)-specific antibody responses after Covishield vaccination for 6 months after vaccination. Design: SARS-CoV-2-specific antibody responses were assessed by enzyme-linked immunosorbent assay of the recombinant receptor-binding domain of SARS-CoV-2 in 381 adults given the Covishield vaccine at baseline ( Results: Over 51% of participants were seropositive at baseline (before vaccination with Covishield), and almost all participants (159/161) became seropositive 1 month after the second dose. Antibody levels peaked 1 month after receipt of the second dose of vaccine, and decreased by 4 months after the first dose; the lowest responses were found 6 months after the first dose, although antibody responses and responder frequencies remained significantly higher compared with baseline ( Conclusions: These findings help to elucidate the longevity of vaccine-specific antibody responses following vaccination with Covishield, and provide information relevant to the planning of booster doses after the initial two doses of vaccine.

Indexed as

AntibodiesBangladeshComorbidityCovishieldSeropositive

Identifiers

PMID35720155
PMCPMC9050186

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.