Evidence map›Paper›PMID 35719892›Full record

ArticlePNAS nexus2022

Indole modulates cooperative protein-protein interactions in the flagellar motor.

Rachit Gupta, Kathy Y Rhee, Sarah D Beagle, Ravi Chawla, Nicolas Perdomo, Steve W Lockless, Pushkar P Lele

Open access · goldAbstract read
In one paragraph

Article in PNAS nexus, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.0field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Article
  3. Indole-3-acetic acid (IAA) protectsApplied and environmental microbiology · 2025
    Article
  4. Article
  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Rachit GuptaArtie McFerrin Department of Chemical Engineering, Texas A&M University, College Station, TX 77843-3122, USA.
Kathy Y RheeArtie McFerrin Department of Chemical Engineering, Texas A&M University, College Station, TX 77843-3122, USA.
Sarah D BeagleDepartment of Biology, Washington University in St. Louis, St. Louis, Missouri, 63130, USA.
Ravi ChawlaDepartment of Integrative Structural and Computational Biology, Scripps Research, La Jolla, CA 92037, USA.
Nicolas PerdomoArtie McFerrin Department of Chemical Engineering, Texas A&M University, College Station, TX 77843-3122, USA.
Steve W LocklessDepartment of Biology, Texas A&M University, College Station, TX 77843-3258, USA.
Pushkar P LeleArtie McFerrin Department of Chemical Engineering, Texas A&M University, College Station, TX 77843-3122, USA.ORCID 0000-0002-2894-3487
Texas A&M University · USScripps Institution of Oceanography · USWashington University in St. Louis · US

Funding

Mechanical Regulation of Ultra-Sensitivity in E. Coli Flagellar MotorsR01GM123085 · NIGMS · TEXAS ENGINEERING EXPERIMENT STATION · PI LELE, PUSHKAR PRAKASH · 2017 to 2025
$1.8M
Physiological Role for Cation Channels in BacteriaR01GM132436 · NIGMS · TEXAS A&M UNIVERSITY · PI SIEGELE, DEBORAH A. · 2019 to 2022
$1.6M
NIGMS NIH HHS R01 GM123085NIGMS NIH HHS R01 GM132436
6 · The paper itself

Abstract

Indole is a major component of the bacterial exometabolome, and the mechanisms for its wide-ranging effects on bacterial physiology are biomedically significant, although they remain poorly understood. Here, we determined how indole modulates the functions of a widely conserved motility apparatus, the bacterial flagellum. Our experiments in

Indexed as

chemoreceptorschemotaxisexometabolomePMFswitching

Identifiers

PMID35719892
PMCPMC9205328
OpenAlexW4225125668

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.