ArticleRoyal Society open science2022
Comparing the age and sex trajectories of SARS-CoV-2 morbidity and mortality with other respiratory pathogens.
Article in Royal Society open science, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed, 18 citations in OpenAlex.
- Seasonal influenza vaccination uptake among older adults in Yerevan, Armenia.BMC geriatrics · 2026Article
- Short and long term suppression of host populations by novel pathogens.bioRxiv : the preprint server for biology · 2025Article
- Modeling the impact of vaccine campaigns on the epidemic transmission dynamics of chikungunya virus outbreaks.Nature medicine · 2025Article
- Creating respiratory pathogen-free environments in healthcare and nursing-care settings: a comprehensive review.GeroScience · 2025Review
- Repercussion of SARS-CoV-2 on the Sexual Function in Males: An Updated Review.Infectious disorders drug targets · 2025Review
- Sex differences in acute respiratory tract infections-multi-year analysis based on data from a large tertiary care medical center in Israel.Frontiers in public health · 2025Article
- Dynamics of measles immunity from birth and following vaccination.Nature microbiology · 2024Article
- Application of Machine Learning Prediction of Individual SARS-CoV-2 Vaccination and Infection Status to the French Serosurveillance Survey From March 2020 to 2022: Cross-Sectional Study.JMIR public health and surveillance · 2023Article
- Maternally derived antibody titer dynamics and risk of hospitalized infant dengue disease.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Comparing the age and sex trajectories of SARS-CoV-2 morbidity and mortality with other respiratory pathogens.Royal Society open science · 2022Article
- COVID-19 hospitalization rates rise exponentially with age, inversely proportional to thymic T-cell production.Journal of the Royal Society, Interface · 2021Article
Corrections and comments
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Authors and funding
10 authors at 6 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Comparing age and sex differences in SARS-CoV-2 hospitalization and mortality with MERS-CoV, seasonal coronaviruses, influenza and other health outcomes opens the way to generating hypotheses as to underlying mechanisms driving disease risk. Using 60-year-olds as a reference age group, we find that relative rates of hospitalization and mortality associated with the emergent coronaviruses are lower during childhood and start to increase earlier (around puberty) as compared with influenza and seasonal coronaviruses. The changing distribution of disease risk by age for emerging pathogens appears to broadly track the gradual deterioration of the immune system (immunosenescence), which starts around puberty. By contrast, differences in severe disease risk by age from endemic pathogens are more decoupled from the immune ageing process. Intriguingly, age-specific sex differences in hospitalizations are largely similar across endemic and emerging infections. We discuss potential mechanisms that may be associated with these patterns.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.