Evidence map›Paper›PMID 35719875›Full record

ArticlePerspectives on behavior science2022

A Brief Introduction to Human Behavioral Pharmacology: Methods, Design Considerations and Ethics.

William W Stoops

Abstract read
In one paragraph

Article in Perspectives on behavior science, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author.

William W StoopsUniversity of Kentucky, 1100 Veterans Drive, Medical Behavioral Science Building Room 140, Lexington, KY 40536-0086 USA.ORCID 0000-0002-8502-0160

Funding

Influence of 5-HT1b Activation on the Abuse Related Effects of CocaineR01DA052203 · NIDA · UNIVERSITY OF KENTUCKY · PI STOOPS, WILLIAM WALTON · 2021 to 2022
$1.3M
Influence of Orexin Antagonism on Motivation for CocaineR01DA048617 · NIDA · UNIVERSITY OF KENTUCKY · PI STOOPS, WILLIAM WALTON · 2019 to 2020
$1.1M
NIDA NIH HHS R01 DA048617NIDA NIH HHS R01 DA052203
6 · The paper itself

Abstract

Human behavioral pharmacology methods have been used to rigorously evaluate the effects of a range of centrally acting drugs in humans under controlled conditions for decades. Methods like drug self-administration and drug discrimination have been adapted from nonhuman laboratory animal models. Because humans have the capacity to communicate verbally, self-report methods are also commonly used to understand drug effects. This perspective article provides an overview of these traditional human behavioral pharmacology methods and introduces some novel methodologies that have more recently been adapted for use in the field. Design (e.g., using placebo controls, testing multiple doses) and ethical (e.g., avoiding enrollment of individuals seeking treatment, determining capacity to consent) considerations that must be addressed when conducting these types of studies are also described.

Indexed as

BehaviorDiscriminative stimulus effectsHumanPharmacologyReinforcing effectsSubjective effects

Identifiers

PMID35719875
PMCPMC9163231

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.