Evidence map›Paper›PMID 35719861›Full record

ArticleJournal of clinical and experimental hepatology

Post-COVID-19 Cholestasis: A Case Series and Review of Literature.

Anand V Kulkarni, Amit Khelgi, Anuradha Sekaran, Raghuram Reddy, Mithun Sharma, Sowmya Tirumalle, Baqar A Gora, Arjun Somireddy, Jignesh Reddy, Balachandran Menon and 2 more

Open access · greenAbstract readCase Reports
In one paragraph

Article in Journal of clinical and experimental hepatology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
3.5field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 25 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Post-COVID-19 cholangiopathy: Systematic review.World journal of methodology · 2023
    Article
  6. Review
  7. Article
  8. Review
  9. Review
  10. Review
  11. Article
  12. COVID-19-Associated Liver Injury.Hepatic medicine : evidence and research · 2023
    Review
  13. Article
  14. Article
  15. Article
  16. Review
  17. COVID-related Vanishing Bile Duct Syndrome (VBDS).Journal of clinical and experimental hepatology
    Article
  18. Post-COVID-19 Cholangiopathy: A Systematic Review.Journal of clinical and experimental hepatology
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Anand V KulkarniDepartment of Hepatology, AIG Hospitals, Hyderabad, India.
Amit KhelgiDepartment of Microbiology, K S Hegde Medical Academy, Mangalore, India.
Anuradha SekaranDepartment of Pathology, AIG Hospitals, Hyderabad, India.
Raghuram ReddyDepartment of Liver Transplantation, AIG Hospitals, Hyderabad, India.
Mithun SharmaDepartment of Hepatology, AIG Hospitals, Hyderabad, India.
Sowmya TirumalleDepartment of Hepatology, AIG Hospitals, Hyderabad, India.
Baqar A GoraDepartment of Hepatology, AIG Hospitals, Hyderabad, India.
Arjun SomireddyDepartment of Radiology, AIG Hospitals, Hyderabad, India.
Jignesh ReddyDepartment of Radiology, AIG Hospitals, Hyderabad, India.
Balachandran MenonDepartment of Liver Transplantation, AIG Hospitals, Hyderabad, India.
Duvvur N ReddyDepartment of Hepatology, AIG Hospitals, Hyderabad, India.
Nagaraja P RaoDepartment of Hepatology, AIG Hospitals, Hyderabad, India.
Global Hospitals · INK S Hegde Medical Academy · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Coronavirus disease-2019 (COVID-19) cholangiopathy is a recently known entity. There are very few reports of liver transplantation (LT) for COVID-19-induced cholangiopathy. It is well known that vaccines can prevent severe disease and improve outcomes. However, there are no reports on the impact of COVID-19 vaccines on cholestasis. Therefore, we aimed to compare the course and outcome of patients who developed cholestasis following COVID-19 infection among vaccinated and unvaccinated individuals. Results: Eight unvaccinated and seven vaccinated individuals developed cholestasis following COVID-19 infection. Baseline demographics, presentation, severity, and management of COVID-19 were similar in both groups. However, patients in the unvaccinated group had a protracted course. The peak ALP was 312 (239-517) U/L in the vaccinated group and 571.5 (368-1058) U/L in the unvaccinated group ( Conclusion: Post-COVID-19 cholestasis is associated with high morbidity and mortality, meriting early identification and appropriate management. Vaccination can modify the course of severe COVID-19 infection and improve outcomes.

Indexed as

ALP, alkaline phosphataseALT, alanine transaminaseAST, aspartate transaminaseCOVID-19, coronavirus disease-2019DDLT, deceased donor living transplantationGGT, γ-glutamyl transpeptidaseLDLT, living donor liver transplantationliver function testliver transplantationplasma exchangeSARS-CoV-2, severe acute respiratory syndrome coronavirus 2UDCA, ursodeoxycholic acidULN, upper limit of normalvaccination

Identifiers

PMID35719861
PMCPMC9187855
OpenAlexW4283215146

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.