Evidence map›Paper›PMID 35719607›Full record

ArticleFrontiers in public health2022

Physical Obstruction of Nasal Cavities With Subsequent Asphyxia, Causes Lethality of Rats in an Acute Inhalation Study With Hydrophobic HMDZ Surface-Treated Synthetic Amorphous Silica (SAS).

Nils Krueger, Klaus Weber, Nils Warfving, Alex Vitali, Jürgen Nolde, Tobias B Schuster, Gustav Gerd Bruer, Otto Creutzenberg, Benno Wessely, Michael Stintz and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in public health, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Nils KruegerEvonik Operations GmbH, Smart Materials, Hanau, Germany.
Klaus WeberAnaPath Services GmbH, Liestal, Switzerland.
Nils WarfvingAnaPath Services GmbH, Liestal, Switzerland.
Alex VitaliAnaPath Services GmbH, Liestal, Switzerland.
Jürgen NoldeGrace Europe Holding GmbH, Worms, Germany.
Tobias B SchusterEvonik Operations GmbH, Smart Materials, Hanau, Germany.
Gustav Gerd BruerDepartment of Inhalation Toxicology, Fraunhofer Institute for Toxicology and Experimental Medicine (Fh-ITEM), Hannover, Germany.
Otto CreutzenbergDepartment of Inhalation Toxicology, Fraunhofer Institute for Toxicology and Experimental Medicine (Fh-ITEM), Hannover, Germany.
Benno WesselyInstitute of Process Engineering and Environmental Technology, Research Group Mechanical Process Engineering, Technische Universität Dresden, Dresden, Germany.
Michael StintzInstitute of Process Engineering and Environmental Technology, Research Group Mechanical Process Engineering, Technische Universität Dresden, Dresden, Germany.
Valerie MoiseCabot Corporation, Corporate SHE - Product Safety and Toxicology, Loncin, Belgium.
Marco KellertWacker Chemie AG, Burghausen, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The aim of the present study was to understand the mechanism of lethality associated with high dose inhalation of a low-density hydrophobic surface-treated SAS observed in some acute inhalation studies. It was demonstrated that physical obstruction of the upper respiratory tract (nasal cavities) caused the effects observed. Hydrophobic surface-treated SAS was inhaled (flow-past, nose-only) by six Wistar rats (three males and three females) in an acute toxicity study at a concentration of ~500 mg/m

Indexed as

Inhalation ExposureSilicon DioxideAerosolsAnimalsAsphyxiaFemaleHydrophobic and Hydrophilic InteractionsMaleNasal CavityRatsRats, WistarAerosolsSilicon Dioxideasphyxiacontact angleinhalationphysical obstructionratsuffocationsynthetic amorphous silica

Identifiers

PMID35719607
PMCPMC9204156

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.