Evidence map›Paper›PMID 35719240›Full record

ArticleJASA express letters2022

Estimated cochlear neural degeneration is associated with loudness hypersensitivity in individuals with normal audiograms.

Kelly N Jahn, Kenneth E Hancock, Stéphane F Maison, Daniel B Polley

Open access · diamondAbstract read
In one paragraph

Article in JASA express letters, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.9field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 9 citations in OpenAlex.

  1. Parallel Age-Related Cochlear Neural Degeneration and Cortical Gain Adaptation in Normal-Hearing Humans.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026
    Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Clinical and investigational tools for monitoring noise-induced hyperacusis.The Journal of the Acoustical Society of America · 2022
    Review
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Kelly N JahnEaton-Peabody Laboratories, Massachusetts Eye and Ear, Boston, Massachusetts 02114, USA kelly.jahn@utdallas.edu, ken_hancock@meei.harvard.edu, stephane_maison@meei.harvard.edu, daniel_polley@meei.harvard.edu.ORCID https://orcid.org/0000-0002-5832-5137
Kenneth E HancockEaton-Peabody Laboratories, Massachusetts Eye and Ear, Boston, Massachusetts 02114, USA kelly.jahn@utdallas.edu, ken_hancock@meei.harvard.edu, stephane_maison@meei.harvard.edu, daniel_polley@meei.harvard.edu.
Stéphane F MaisonEaton-Peabody Laboratories, Massachusetts Eye and Ear, Boston, Massachusetts 02114, USA kelly.jahn@utdallas.edu, ken_hancock@meei.harvard.edu, stephane_maison@meei.harvard.edu, daniel_polley@meei.harvard.edu.
Daniel B PolleyEaton-Peabody Laboratories, Massachusetts Eye and Ear, Boston, Massachusetts 02114, USA kelly.jahn@utdallas.edu, ken_hancock@meei.harvard.edu, stephane_maison@meei.harvard.edu, daniel_polley@meei.harvard.edu.
Eaton (United States) · US

Funding

Synaptopathy, Neural Pathophysiology and Suprathreshold Processing in Gerbils with Normal or Elevated ThresholdsP50DC015857 · NIDCD · MASSACHUSETTS EYE AND EAR INFIRMARY · PI M. Charles Liberman · 2017 to 2026
$28.1M
Neural Signatures of Enhanced Central Auditory Gain in HyperacusisK01DC019647 · NIDCD · UNIVERSITY OF TEXAS DALLAS · PI JAHN, KELLY NICOLE · 2021 to 2023
$415k
NIDCD NIH HHS K01 DC019647NIDCD NIH HHS P50 DC015857
6 · The paper itself

Abstract

In animal models, cochlear neural degeneration (CND) is associated with excess central gain and hyperacusis, but a compelling link between reduced cochlear neural inputs and heightened loudness perception in humans remains elusive. The present study examined whether greater estimated cochlear neural degeneration (eCND) in human participants with normal hearing thresholds is associated with heightened loudness perception and sound aversion. Results demonstrated that loudness perception was heightened in ears with greater eCND and in subjects who self-report loudness aversion via a hyperacusis questionnaire. These findings suggest that CND may be a potential trigger for loudness hypersensitivity.

Identifiers

PMID35719240
PMCPMC9199082
OpenAlexW4282601813

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.