Evidence map›Paper›PMID 35719121›Full record

SynthesisArtificial organs2022

Machine learning and artificial intelligence in cardiac transplantation: A systematic review.

Vinci Naruka, Arian Arjomandi Rad, Hariharan Subbiah Ponniah, Jeevan Francis, Robert Vardanyan, Panagiotis Tasoudis, Dimitrios E Magouliotis, George L Lazopoulos, Mohammad Yousuf Salmasi, Thanos Athanasiou

Open access · hybridAbstract readSystematic Review
In one paragraph

Synthesis in Artificial organs, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed, 3 pooled it
9.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 3 syntheses or guidelines pooled it, 48 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. XGBoost Outperforms Traditional Transplant Regulatory Models Based on Regression.Annals of surgery open : perspectives of surgical history, education, and clinical approaches · 2026
    Article
  5. Review
  6. Review
  7. Review
  8. Artificial intelligence in heart failure.The Egyptian heart journal : (EHJ) : official bulletin of the Egyptian Society of Cardiology · 2026
    Review
  9. Review
  10. Review
  11. Article
  12. The ethical considerations of integrating artificial intelligence into surgery: a review.Interdisciplinary cardiovascular and thoracic surgery · 2025
    Review
  13. Review
  14. Review
  15. Article
  16. Review
  17. Review
  18. Review
  19. The molecular mechanisms of cardiac development and related diseases.Signal transduction and targeted therapy · 2024
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 2 countries.

Vinci NarukaDepartment of Cardiothoracic Surgery, Imperial College NHS Trust, Hammersmith Hospital, London, UK.
Arian Arjomandi RadDepartment of Surgery and Cancer, Faculty of Medicine, Imperial College London, London, UK.ORCID https://orcid.org/0000-0002-4931-4049
Hariharan Subbiah PonniahDepartment of Surgery and Cancer, Faculty of Medicine, Imperial College London, London, UK.ORCID https://orcid.org/0000-0002-5471-9120
Jeevan FrancisFaculty of Medicine, University of Edinburgh, Edinburgh, UK.
Robert VardanyanDepartment of Surgery and Cancer, Faculty of Medicine, Imperial College London, London, UK.
Panagiotis TasoudisDepartment of Cardiothoracic Surgery, University Hospital Thessaly, Larissa, Greece.
Dimitrios E MagouliotisDepartment of Cardiothoracic Surgery, University Hospital Thessaly, Larissa, Greece.
George L LazopoulosDepartment of Cardiothoracic Surgery, University Hospital Thessaly, Larissa, Greece.
Mohammad Yousuf SalmasiDepartment of Surgery and Cancer, Faculty of Medicine, Imperial College London, London, UK.
Thanos AthanasiouDepartment of Cardiothoracic Surgery, Imperial College NHS Trust, Hammersmith Hospital, London, UK.
Imperial College London · GBUniversity Hospital of Larissa · GRImperial College Healthcare NHS Trust · GBUniversity of Edinburgh · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThis review aims to systematically evaluate the currently available evidence investigating the use of artificial intelligence (AI) and machine learning (ML) in the field of cardiac transplantation. Furthermore, based on the challenges identified we aim to provide a series of recommendations and a knowledge base for future research in the field of ML and heart transplantation.

methodsA systematic database search was conducted of original articles that explored the use of ML and/or AI in heart transplantation in EMBASE, MEDLINE, Cochrane database, and Google Scholar, from inception to November 2021.

resultsOur search yielded 237 articles, of which 13 studies were included in this review, featuring 463 850 patients. Three main areas of application were identified: (1) ML for predictive modeling of heart transplantation mortality outcomes; (2) ML in graft failure outcomes; (3) ML to aid imaging in heart transplantation. The results of the included studies suggest that AI and ML are more accurate in predicting graft failure and mortality than traditional scoring systems and conventional regression analysis. Major predictors of graft failure and mortality identified in ML models were: length of hospital stay, immunosuppressive regimen, recipient's age, congenital heart disease, and organ ischemia time. Other potential benefits include analyzing initial lab investigations and imaging, assisting a patient with medication adherence, and creating positive behavioral changes to minimize further cardiovascular risk.

conclusionML demonstrated promising applications for improving heart transplantation outcomes and patient-centered care, nevertheless, there remain important limitations relating to implementing AI into everyday surgical practices.

Indexed as

Artificial IntelligenceHeart TransplantationDatabases, FactualHumansLength of StayMachine Learningartificial intelligencecardiac transplantationheart transplantationmachine learning

Identifiers

PMID35719121
PMCPMC9545856
OpenAlexW4283213661

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.