ArticleInternational journal of geriatric psychiatry2022
Reduced kidney function is associated with poorer domain-specific cognitive performance in community-dwelling older adults.
Article in International journal of geriatric psychiatry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- It "Made a Huge Difference when He had a Dry Bed in the Morning": Impacts of Dementia-Related Incontinence on Unpaid Carers' Sleep, Health, and Quality of Life.Dementia (London, England) · 2026Article
- Serum Creatinine Clearance and Cognitive Function in Older Adults: Mediating Effects of Systemic Inflammatory Response Index.Brain and behavior · 2026Article
- Article
- Cognitive impairment and health outcomes in non-dialysis chronic kidney disease: a systematic review and meta-analysis.Clinical kidney journal · 2025Article
- Uremic Toxins, CKD, and Cognitive Dysfunction.Journal of the American Society of Nephrology : JASN · 2025Review
- A new approach for cognitive impairment pattern in chronic kidney disease.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2024Article
- Association of cognitive impairment with the interaction between chronic kidney disease and depression: findings from NHANES 2011-2014.BMC psychiatry · 2024Article
- Methodological challenges and biases in the field of cognitive function among patients with chronic kidney disease.Frontiers in medicine · 2023Review
- Reduced kidney function is associated with poorer domain-specific cognitive performance in community-dwelling older adults.International journal of geriatric psychiatry · 2022Article
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Authors and funding
13 authors.
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Abstract
objectivesWhilst chronic kidney disease has been associated with cognitive impairment, the association between reduced estimated Glomerular Filtration Rate (eGFR) and domain-specific cognitive performance is less clear and may represent an important target for the promotion of optimal brain health in older adults.
methodsParticipants aged >60 years from the Trinity-Ulster-Department of Agriculture study underwent detailed cognitive assessment using the Mini-Mental State Examination (Mini-Mental State Examination (MMSE)), Frontal Assessment Battery (FAB) and Repeatable Battery for Assessment of Neuropsychological Status (RBANS). Poisson and linear regression models assessed the relationship between eGFR strata and cognitive performance.
resultsIn 4887 older adults (73.9 ± 8.3 years; 67.7% female), declining eGFR strata was associated with greater likelihood of error on the MMSE/FAB and poorer overall performance on the RBANS. Following robust covariate adjustment, findings were greatest for GFR <45 ml/ml/1.73 m
conclusionsReduced kidney function was associated with poorer global and domain-specific neuropsychological performance. Associations were strongest with eGFR <45 ml/min/1.73 m
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