Evidence map›Paper›PMID 35718993›Full record

ArticleJournal of clinical laboratory analysis2022

Carbapenem antibiotic stress increases bla

Huimin Chen, Na Li, Fang Wang, Lei Wang, Wei Liang

Open access · goldAbstract read
In one paragraph

Article in Journal of clinical laboratory analysis, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.9field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 13 citations in OpenAlex.

  1. High burden of blaBMC microbiology · 2026
    Article
  2. Emergence of carbapenem-resistantFrontiers in microbiology · 2026
    Article
  3. Comparative genomic study of blaScientific reports · 2025
    Article
  4. Article
  5. Plasmid diversity in Klebsiella pneumoniae ST307 co-producing KPC plus NDM recovered during the COVID-19 pandemic.Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases · 2025
    Article
  6. Article
  7. Article
  8. Carbapenem antibiotic stress increases blaJournal of clinical laboratory analysis · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 1 country.

Huimin ChenLianyungang Second People's Hospital affiliated to Jiangsu University, Lianyungang, China.
Na LiLianyungang Second People's Hospital Affiliated to Bengbu Medical College, Lianyungang, China.
Fang WangLianyungang Second People Hospital, Lianyungang, China.
Lei WangJiangsu University of Science and Technology, Zhenjiang, China.
Wei LiangLianyungang Second People's Hospital affiliated to Jiangsu University, Lianyungang, China.ORCID https://orcid.org/0000-0002-1610-0554
Xian Yang Central Hospital · CNBengbu Medical College · CNJiangsu University of Science and Technology · CNTongren Hospital · CN

Funding

Jiangsu Provinceliangwei BK20191210liangwei BRA2019248Lianyungang Science and Technology BureauNatural Science Foundation of Jiangsu Province
6 · The paper itself

Abstract

backgroundThe clinical isolation rates of carbapenem-resistant Klebsiella pneumoniae (CR-KP) continue to increase. In China, clinical CR-KP isolates are mainly attributed to the bla

methodsThirty-seven CR-KP isolates were collected at the Second People's Hospital of Lianyungang City between January 2020 and March 2021, with no duplicate isolates, and were screened for the bla

resultsAmong the 37 CR-KP strains isolated, only the bla

conclusionCarbapenem-resistant Klebsiella pneumoniae isolates may have multiple pathways to achieve high levels of carbapenem resistance, and moderate carbapenem pressure can increase the copy number of KPC enzyme genes in CRKP strains and enhance the degree of carbapenem resistance in the strains.

Indexed as

Carbapenem-Resistant EnterobacteriaceaeKlebsiella InfectionsAnti-Bacterial AgentsBacterial Proteinsbeta-LactamasesCarbapenemsDNA Copy Number VariationsHumansImipenemKlebsiella pneumoniaeMicrobial Sensitivity TestsAnti-Bacterial AgentsBacterial Proteinsbeta-LactamasesCarbapenemsImipenemcarbapenemasedrug resistanceKlebsiella pneumoniaerelative gene copy number

Identifiers

PMID35718993
PMCPMC9280016
OpenAlexW4283160853

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.