Evidence map›Paper›PMID 35718985›Full record

ArticleJournal of cosmetic dermatology2023

A prospective multicenter clinical trial evaluating the efficacy and safety of a hyaluronic acid-based filler with Tri-Hyal technology in the treatment of lips and the perioral area.

Agnès Ehlinger-David, Mihai Gorj, Frédéric Braccini, Federico Loreto, Anne Grand-Vincent, Philippe Garcia, Maryna Taieb, Laurent Benadiba, Isabelle Catoni, Elena Rumyantseva Mathey and 8 more

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of cosmetic dermatology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 4 syntheses or guidelines pooled it.

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  11. Histological Comparison of Lipofilling and Hyaluronic Acid Filler Injection 30 Days after Simulation in Rats.Doklady biological sciences : proceedings of the Academy of Sciences of the USSR, Biological sciences sections · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Agnès Ehlinger-DavidPrivate clinic, Thionville, France.
Mihai GorjPrivate clinic, Paris, France.
Frédéric BracciniPrivate clinic, Nice, France.
Federico LoretoPrivate clinic, Paris, France.
Anne Grand-VincentPrivate clinic, Paris, France.
Philippe GarciaPrivate clinic, Paris, France.
Maryna TaiebPrivate clinic, Paris, France.
Laurent BenadibaPrivate clinic, Paris, France.
Isabelle CatoniPrivate clinic, Neuilly-sur-Seine, France.
Elena Rumyantseva MatheyPrivate clinic, Paris, France.
Jean-Jacques DeutschPrivate clinique, Paris, France.
Philippe BahadoranPrivate clinic, Nice, France.
Thibaud VincentPrivate clinic, Paris, France.
Michel DavidPrivate clinic, Metz, France.
Hugues CartierPrivate clinic, Arras, France.
Karim NadraFillmed Laboratories, Paris, France.
Nicholas MoellhoffDivision of Hand, Plastic and Aesthetic Surgery, University Hospital, LMU Munich, Munich, Germany.
Ferial FanianFillmed Laboratories, Paris, France.ORCID https://orcid.org/0000-0003-3900-5506

Funding

Laboratoires FILLMED Paris, France
6 · The paper itself

Abstract

backgroundAge-related changes of facial soft tissue cause clinical signs of facial aging such as lip atrophy, marionette lines, and an accentuated nasolabial fold. These changes can be modified using dermal fillers.

aimsTo evaluate efficacy, longevity, and safety of a cross-linked hyaluronic acid-based filler with Tri-Hyal technology in the treatment of lips, nasolabial folds, and marionette lines. MATERIALS AND

methodsThis prospective, multi-center trial evaluated injections of three different areas (lips, nasolabial fold alone, or with marionette wrinkles) with a soft tissue filler containing 25 mg/ml cross-linked hyaluronic acid and 0.3% lidocaine. Primary endpoint was the aesthetic correction 3 weeks after one injection session without touch-up. Follow-up was 18 months. Assessments were performed using the Global Aesthetic Score (GAS), clinical scoring based on photographic scales, high-frequency ultrasound imaging, and the Global Aesthetic Improvement Scale (GAIS).

resultsIn total, 100 subjects were injected. GAS improved significantly for all treatment indications at 3 weeks (p < 0.0001). Success rates were highest for nasolabial folds (98.4%), followed by marionette lines (94.4%) and lips (73.5%). After 18 months post-injection, success was observed in 91%, 88%, and 33% of subjects injected into nasolabial folds, marionette lines, and lips, respectively. GAIS scored highest for nasolabial folds (SGAIS: 71%; IGAIS: 40%), followed by marionette lines (SGAIS: 56%; IGAIS: 33%) and lips (SGAIS: 30%; IGAIS: 22%) at 18 months follow-up.

conclusionsThe filler demonstrated high efficacy and safety in all indications. Regional differences in longevity were evident. Thus, the necessity of regional retreatments should be discussed with patients before injection.

Indexed as

Cosmetic TechniquesDermal FillersSkin AgingHumansHyaluronic AcidLipNasolabial FoldProspective StudiesTreatment OutcomeDermal FillersHyaluronic Aciddermal fillerfacial aginghyaluronic acidlips volumeperioral rejuvenation

Identifiers

PMID35718985
PMCPMC10087550

What OpenQuestion holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.