Evidence map›Paper›PMID 35718840›Full record

ArticleMolecular diversity2023

PTSA-catalyzed selective synthesis and antibacterial evaluation of 1,2-disubstituted benzimidazoles.

Jiaxu Fu, Yuandong Yue, Kejun Liu, Shuang Wang, Yiliang Zhang, Qing Su, Qiang Gu, Feng Lin, Yumin Zhang

Abstract read
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Article in Molecular diversity, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
1.7field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 16 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Jiaxu FuDepartment of Chemical Engineering and Applied Chemistry, College of Chemistry, Jilin University, Changchun, 130012, People's Republic of China.
Yuandong YueSchool of Life Sciences, Jilin University, Changchun, 130012, People's Republic of China.
Kejun LiuDepartment of Chemical Engineering and Applied Chemistry, College of Chemistry, Jilin University, Changchun, 130012, People's Republic of China.
Shuang WangDepartment of Chemical Engineering and Applied Chemistry, College of Chemistry, Jilin University, Changchun, 130012, People's Republic of China.
Yiliang ZhangDepartment of Chemical Engineering and Applied Chemistry, College of Chemistry, Jilin University, Changchun, 130012, People's Republic of China.
Qing SuDepartment of Chemical Engineering and Applied Chemistry, College of Chemistry, Jilin University, Changchun, 130012, People's Republic of China.
Qiang GuDepartment of Chemical Engineering and Applied Chemistry, College of Chemistry, Jilin University, Changchun, 130012, People's Republic of China.
Feng LinSchool of Life Sciences, Jilin University, Changchun, 130012, People's Republic of China.
Yumin ZhangDepartment of Chemical Engineering and Applied Chemistry, College of Chemistry, Jilin University, Changchun, 130012, People's Republic of China. zhang_ym@jlu.edu.cn.
Jilin University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Herein, we developed a convenient and efficient method via protonation of p-toluenesulfonic acid promoted cyclocondensation of o-phenylenediamine and aldehydes for selectively synthesizing 1,2-disubstituted benzimidazoles. This method displayed broad substrate adaptability and afforded the desired products in moderate to excellent yield in short reaction time. The effect of different substituents on the yield was investigated by extending optimum reaction conditions, which was further confirmed by theoretical calculations. It suggested that the surface electrostatic potential of oxygen atom and nitrogen atom on the substrates played important role in the synthesis of 1,2-disubstituted benzimidazoles. Besides, the crystal structure of compound 2t in the orthorhombic space group P2(1)/c was presented. Also, the anti-mycolicibacterium smegmatis (MC2155) activity was evaluated using rifampicin as a positive control. The products (2a, 2b, 2c, 2i, 2j, 2k, 2m) showed good antibacterial activities which were comparable to rifampicin.

Indexed as

BenzimidazolesRifampinAnti-Bacterial AgentsCatalysisPyrenes1,3,6,8-pyrene tetrasulfonateAnti-Bacterial AgentsBenzimidazolesPyrenesRifampinBenzimidazolesBiological activityCatalysisSelective synthesisTheoretical calculation

Identifiers

PMID35718840
OpenAlexW4283119191

What OpenQuestion holds

Textmetadata
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.