Evidence map›Paper›PMID 35717669›Full record

ArticleSmall (Weinheim an der Bergstrasse, Germany)2022

Development of Biodegradable Osteopromotive Citrate-Based Bone Putty.

Xinyu Tan, Ethan Gerhard, Yuqi Wang, Richard T Tran, Hui Xu, Su Yan, Elias B Rizk, April D Armstrong, Yuxiao Zhou, Jing Du and 2 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Small (Weinheim an der Bergstrasse, Germany), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
4.3field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 31 citations in OpenAlex.

  1. Trial
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  6. Article
  7. Novel Bioresorbable Bone Wax for Potentiated Hemostasis and Osteogenesis.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  8. Article
  9. Article
  10. Review
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  12. Article
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  16. Review
  17. Functional hydrogels for the repair and regeneration of tissue defects.Frontiers in bioengineering and biotechnology · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 2 countries.

Xinyu TanDepartment of Cell Biology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, Guangdong Province, 510515, China.
Ethan GerhardDepartment of Biomedical Engineering, Materials Research Institute, The Huck Institutes of the Life Sciences, The Pennsylvania State University, University Park, PA, 16802, USA.
Yuqi WangDepartment of Biomedical Engineering, Materials Research Institute, The Huck Institutes of the Life Sciences, The Pennsylvania State University, University Park, PA, 16802, USA.
Richard T TranDepartment of Biomedical Engineering, Materials Research Institute, The Huck Institutes of the Life Sciences, The Pennsylvania State University, University Park, PA, 16802, USA.
Hui XuDepartment of Biomedical Engineering, Materials Research Institute, The Huck Institutes of the Life Sciences, The Pennsylvania State University, University Park, PA, 16802, USA.
Su YanDepartment of Biomedical Engineering, Materials Research Institute, The Huck Institutes of the Life Sciences, The Pennsylvania State University, University Park, PA, 16802, USA.
Elias B RizkDepartment of Neurosurgery, College of Medicine, The Pennsylvania State University, Hershey, PA, 17033, USA.
April D ArmstrongDepartment of Orthopaedics and Rehabilitation, College of Medicine, The Pennsylvania State University, Hershey, PA, 17033, USA.
Yuxiao ZhouDepartment of Mechanical Engineering, The Pennsylvania State University, University Park, PA, 16802, USA.
Jing DuDepartment of Mechanical Engineering, The Pennsylvania State University, University Park, PA, 16802, USA.
Xiaochun BaiDepartment of Cell Biology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, Guangdong Province, 510515, China.
Jian YangDepartment of Biomedical Engineering, Materials Research Institute, The Huck Institutes of the Life Sciences, The Pennsylvania State University, University Park, PA, 16802, USA.ORCID 0000-0003-0695-828X
Pennsylvania State University · USThird Affiliated Hospital of Southern Medical University · CN

Funding

Citrate Metabonegenic Regulation for the next Generation of Orthopedic Biomaterial DesignR01AR072731 · NIAMS · PENNSYLVANIA STATE UNIVERSITY, THE · PI YANG, JIAN · 2018 to 2022
$1.7M
NIAMS NIH HHS AR072731NIAMS NIH HHS R01 AR072731
6 · The paper itself

Abstract

The burden of bone fractures demands development of effective biomaterial solutions, while additional acute events such as noncompressible bleeding further motivate the search for multi-functional implants to avoid complications including osseous hemorrhage, infection, and nonunion. Bone wax has been widely used in orthopedic bleeding control due to its simplicity of use and conformation to irregular defects; however, its nondegradability results in impaired bone healing, risk of infection, and significant inflammatory responses. Herein, a class of intrinsically fluorescent, osteopromotive citrate-based polymer/hydroxyapatite (HA) composites (BPLP-Ser/HA) as a highly malleable press-fit putty is designed. BPLP-Ser/HA putty displays mechanics replicating early nonmineralized bone (initial moduli from ≈2-500 kPa), hydration induced mechanical strengthening in physiological conditions, tunable degradation rates (over 2 months), low swelling ratios (<10%), clotting and hemostatic sealing potential (resistant to blood pressure for >24 h) and significant adhesion to bone (≈350-550 kPa). Simultaneously, citrate's bioactive properties result in antimicrobial (≈100% and 55% inhibition of S. aureus and E. coli) and osteopromotive effects. Finally, BPLP-Ser/HA putty demonstrates in vivo regeneration in a critical-sized rat calvaria model equivalent to gold standard autograft. BPLP-Ser/HA putty represents a simple, off-the-shelf solution to the combined challenges of acute wound management and subsequent bone regeneration.

Indexed as

Bone SubstitutesCitric AcidAnimalsBone and BonesBone RegenerationCitratesDurapatiteEscherichia coliRatsStaphylococcus aureusBone SubstitutesCitratesCitric AcidDurapatitebone puttybone waxcitric acidmetabonegenesisorthopedic biomaterials

Identifiers

PMID35717669
PMCPMC9463100
OpenAlexW4283124516

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.