Evidence map›Paper›PMID 35717643›Full record

ArticleClinical infectious diseases : an official publication of the Infectious Diseases Society of America2023

Tuberculosis Molecular Bacterial Load Assay Reveals Early Delayed Bacterial Killing in Patients With Relapse.

Nyanda Elias Ntinginya, Abhishek Bakuli, Daniel Mapamba, Wilber Sabiiti, Gibson Kibiki, Lilian Tina Minja, Davis Kuchaka, Klaus Reither, Patrick Peter John Phillips, Martin Johan Boeree and 4 more

Abstract read
In one paragraph

Article in Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Insights into the Role of Rifampicin Exposure and Clinical Baseline Covariates on the Response to Pulmonary Tuberculosis Treatment.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2026
    Article
  3. Article
  4. Observational
  5. Review
  6. Article
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Nyanda Elias NtinginyaNational Institute for Medical Research-Mbeya Medical Research Centre, Mbeya, United Republic of Tanzania.
Abhishek BakuliDivision of Infectious Diseases and Tropical Medicine, University Hospital, LMU Munich, Munich, Germany.
Daniel MapambaNational Institute for Medical Research-Mbeya Medical Research Centre, Mbeya, United Republic of Tanzania.
Wilber SabiitiDivision of Infection and Global Health, School of Medicine, University of St Andrews, St Andrews, United Kingdom.
Gibson KibikiEast African Health Research Commission, Bujumbura, Burundi.
Lilian Tina MinjaIfakara Health Institute, Dar Es Salaam, United Republic of Tanzania.
Davis KuchakaKilimanjaro Clinical Research Institute, Moshi, United Republic of Tanzania.
Klaus ReitherIfakara Health Institute, Dar Es Salaam, United Republic of Tanzania.
Patrick Peter John PhillipsCenter for Tuberculosis, University of California, San Francisco, San Francisco, California, USA.
Martin Johan BoereeRadboud Institute of Health Science, Radboud University Medical Center, Nijmegen, The Netherlands.
Stephen H GillespieDivision of Infection and Global Health, School of Medicine, University of St Andrews, St Andrews, United Kingdom.
Michael HoelscherDivision of Infectious Diseases and Tropical Medicine, University Hospital, LMU Munich, Munich, Germany.
Norbert HeinrichDivision of Infectious Diseases and Tropical Medicine, University Hospital, LMU Munich, Munich, Germany.ORCID 0000-0001-9252-7106
Pan African Consortium for the Evaluation of Antituberculosis Antibiotics (PanACEA) Consortium

Funding

Statistical and Data Management Center (SDMC), AIDS Clinical Trials Group (ACTG)UM1AI068634 · NIAID · HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH · PI Marlene Ann Cooper, Michael David Hughes · 2011 to 2026
$246.6M
NIAID NIH HHS UM1 AI068634
6 · The paper itself

Abstract

Bacterial killing in patients with tuberculosis (TB) relapse was compared to that in patients achieving cure, measured by TB molecular bacterial load assay (TB-MBLA) or mycobacteria growth indicator tube (MGIT) time to positivity (TTP). TB-MBLA in 4 relapsed patients was significantly different compared to 132 cured patients after 2 weeks of treatment; MGIT TTP showed a significant difference from week 8.

Indexed as

Mycobacterium tuberculosisTuberculosisBacterial LoadHumansRecurrenceSputumbiomarkerclinical trialrelapsetuberclosis

Identifiers

PMID35717643
PMCPMC9907486

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.